Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals
Cis-vaccenic acid has been shown to regulate food intake in Bombyx mori, but its potential role in mammals remains unclear. In this study, mice were fed either standard or high-fat diets supplemented with cis-vaccenic acid to evaluate its effects on satiety regulation and related physiological/bioch...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625003007 |
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| Summary: | Cis-vaccenic acid has been shown to regulate food intake in Bombyx mori, but its potential role in mammals remains unclear. In this study, mice were fed either standard or high-fat diets supplemented with cis-vaccenic acid to evaluate its effects on satiety regulation and related physiological/biochemical parameters. The results demonstrated that dietary cis-vaccenic acid enhanced satiation in mice through significant upregulation of cholecystokinin and peptide tyrosine tyrosine expression, ultimately leading to a 16.1 % reduction in weight gain and 34.1 % decrease in food intake. qRT-PCR analysis revealed that cis-vaccenic acid administration downregulated hepatic lipogenesis-related genes (ACC, SREBP-1a, FAS, and SCD-1/SCD-2) while upregulating lipid catabolism-associated genes (PPARα and CPT-1). Histological evaluations showed that cis-vaccenic acid supplementation effectively mitigated HFD-induced hepatic steatosis and adipocyte hypertrophy. No detectable toxicity was observed in cis-vaccenic acid-treated mice. These findings suggest that cis-vaccenic acid may represent a novel therapeutic target for obesity management and related metabolic disorders. |
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| ISSN: | 1756-4646 |