Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin
Oroanthral fistula (anastomosis) is an element preventing the restoration of homeostasis in the maxillary sinus due to the constant flow of microbes from the oral cavity. It is also contributes to frequent exacerbations of maxillary sinusitis. Saprophytic gram-positive cocci and fungi of the oral c...
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Dnipro State Medical University
2021-09-01
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| Series: | Medičnì Perspektivi |
| Online Access: | https://journals.uran.ua/index.php/2307-0404/article/view/242157 |
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| author | I.V. Kovach S.D. Varzhapetian Kh.A. Bunyatyan O.E. Reyzvikh A.A. Babenya T.V. Strogonova |
| author_facet | I.V. Kovach S.D. Varzhapetian Kh.A. Bunyatyan O.E. Reyzvikh A.A. Babenya T.V. Strogonova |
| author_sort | I.V. Kovach |
| collection | DOAJ |
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Oroanthral fistula (anastomosis) is an element preventing the restoration of homeostasis in the maxillary sinus due to the constant flow of microbes from the oral cavity. It is also contributes to frequent exacerbations of maxillary sinusitis. Saprophytic gram-positive cocci and fungi of the oral cavity are dominating representatives of the microbial flora in the maxillary sinus. As the result of research, we found that in the case of maxillary sinusitis with oroantral fistula fungi made up 25.0% of microbiota, gram-positive bacteria – 41.7%, gram-negative bacteria – 33.3%. Gram-positive cocci from the Staphylococcus genus (Staphylococcus aureus and Staphylococcus epidermidis) and fungi (Candida albicans) comprised the biggest proportion of microbial flora that 33.3% and 16.7%, respectively. Slightly decreased levels of monocytes in venous blood was noted in 69.2% of patients. The average value of total serum IgE in group with oroantal fistula was 226.2 (70.4) IU/ml, the result exceeded normal limits almost in 2.26 times. Large circulating immune complexes (CICs) were normal in all patients in the group with iatrogenic maxillary sinusitis. The average lavels of small size CICs was 170.2 (4.23) ОU, which is in 1.06 times higher the upper limit of the norm (160 ОU). Elevated levels of total Ig E in serum of patients with oroanthral fistula indicates allergic sensitization. The detection of increased levels of CICs with small and medium sizes in serum may indicate a susceptibility of this category of patients to the development of immunopathological reactions.
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| format | Article |
| id | doaj-art-81b9ef23c6ac4c21bb17987e37c2bae7 |
| institution | Matheson Library |
| issn | 2307-0404 2786-4804 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Dnipro State Medical University |
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| series | Medičnì Perspektivi |
| spelling | doaj-art-81b9ef23c6ac4c21bb17987e37c2bae72025-06-27T10:23:18ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042786-48042021-09-0126310.26641/2307-0404.2021.3.242157279935Microbial landscape and immune status in maxillary sinusitis of stomatogenic originI.V. Kovach0S.D. Varzhapetian1Kh.A. Bunyatyan2O.E. Reyzvikh3A.A. Babenya4T.V. Strogonova 5Dnipro State Medical University, V. Vernadsky str., 9, Dnipro, 49044Zaporizhzhia State Medical University, Maiakovskyi av., 26, Zaporizhzhia, 69035Dnipro State Medical University, V. Vernadsky str., 9, Dnipro, 49044Institute of Dentistry and Maxillofacial Surgery of the National Academy of Medical Sciences of Ukraine, Rishelevskaya str., 11, Odessa, 65000Institute of Dentistry and Maxillofacial Surgery of the National Academy of Medical Sciences of Ukraine, Rishelevskaya str., 11, Odessa, 65000Zaporizhzhia State Medical University, Maiakovskyi av., 26, Zaporizhzhia, 69035 Oroanthral fistula (anastomosis) is an element preventing the restoration of homeostasis in the maxillary sinus due to the constant flow of microbes from the oral cavity. It is also contributes to frequent exacerbations of maxillary sinusitis. Saprophytic gram-positive cocci and fungi of the oral cavity are dominating representatives of the microbial flora in the maxillary sinus. As the result of research, we found that in the case of maxillary sinusitis with oroantral fistula fungi made up 25.0% of microbiota, gram-positive bacteria – 41.7%, gram-negative bacteria – 33.3%. Gram-positive cocci from the Staphylococcus genus (Staphylococcus aureus and Staphylococcus epidermidis) and fungi (Candida albicans) comprised the biggest proportion of microbial flora that 33.3% and 16.7%, respectively. Slightly decreased levels of monocytes in venous blood was noted in 69.2% of patients. The average value of total serum IgE in group with oroantal fistula was 226.2 (70.4) IU/ml, the result exceeded normal limits almost in 2.26 times. Large circulating immune complexes (CICs) were normal in all patients in the group with iatrogenic maxillary sinusitis. The average lavels of small size CICs was 170.2 (4.23) ОU, which is in 1.06 times higher the upper limit of the norm (160 ОU). Elevated levels of total Ig E in serum of patients with oroanthral fistula indicates allergic sensitization. The detection of increased levels of CICs with small and medium sizes in serum may indicate a susceptibility of this category of patients to the development of immunopathological reactions. https://journals.uran.ua/index.php/2307-0404/article/view/242157 |
| spellingShingle | I.V. Kovach S.D. Varzhapetian Kh.A. Bunyatyan O.E. Reyzvikh A.A. Babenya T.V. Strogonova Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin Medičnì Perspektivi |
| title | Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| title_full | Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| title_fullStr | Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| title_full_unstemmed | Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| title_short | Microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| title_sort | microbial landscape and immune status in maxillary sinusitis of stomatogenic origin |
| url | https://journals.uran.ua/index.php/2307-0404/article/view/242157 |
| work_keys_str_mv | AT ivkovach microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin AT sdvarzhapetian microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin AT khabunyatyan microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin AT oereyzvikh microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin AT aababenya microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin AT tvstrogonova microbiallandscapeandimmunestatusinmaxillarysinusitisofstomatogenicorigin |