Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism
Histamine intolerance is a condition that occurs when there is an imbalance between the accumulation and degradation of histamine within the body. Excess histamine is metabolized and then degraded by two enzymes, of which the most abundant is the vesicular diamine oxidase (DAO). An imbalance or a st...
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2025-06-01
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| author | Gina Cavaliere Egidia Costanzi Beniamino Cenci-Goga Marco Misuraca Giovanna Traina |
| author_facet | Gina Cavaliere Egidia Costanzi Beniamino Cenci-Goga Marco Misuraca Giovanna Traina |
| author_sort | Gina Cavaliere |
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| description | Histamine intolerance is a condition that occurs when there is an imbalance between the accumulation and degradation of histamine within the body. Excess histamine is metabolized and then degraded by two enzymes, of which the most abundant is the vesicular diamine oxidase (DAO). An imbalance or a state of dysbiosis of the intestinal microbiota has been observed in patients with histamine intolerance compared to healthy individuals. Studies indicate that the administration of bifidobacteria or lactobacilli alone or in mixtures can alter colonic microbiota populations and metabolic activities. The present study has evaluated the ability of a probiotic bacterial strain to stimulate the release of cellular DAO from an in vitro model of the human intestinal epithelial barrier. The results indicate that, under the experimental conditions used, probiotic strain <i>Lactiplantibacillus plantarum</i> LP115 has a significant stimulatory effect on DAO secretion in adenocarcinoma cell line HT-29. |
| format | Article |
| id | doaj-art-81805d0b6ad94cc39d737abd63c20ab6 |
| institution | Matheson Library |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-81805d0b6ad94cc39d737abd63c20ab62025-06-25T13:30:45ZengMDPI AGBiology2079-77372025-06-0114673410.3390/biology14060734Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine MetabolismGina Cavaliere0Egidia Costanzi1Beniamino Cenci-Goga2Marco Misuraca3Giovanna Traina4Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, ItalyHistamine intolerance is a condition that occurs when there is an imbalance between the accumulation and degradation of histamine within the body. Excess histamine is metabolized and then degraded by two enzymes, of which the most abundant is the vesicular diamine oxidase (DAO). An imbalance or a state of dysbiosis of the intestinal microbiota has been observed in patients with histamine intolerance compared to healthy individuals. Studies indicate that the administration of bifidobacteria or lactobacilli alone or in mixtures can alter colonic microbiota populations and metabolic activities. The present study has evaluated the ability of a probiotic bacterial strain to stimulate the release of cellular DAO from an in vitro model of the human intestinal epithelial barrier. The results indicate that, under the experimental conditions used, probiotic strain <i>Lactiplantibacillus plantarum</i> LP115 has a significant stimulatory effect on DAO secretion in adenocarcinoma cell line HT-29.https://www.mdpi.com/2079-7737/14/6/734<i>Lactiplantibacillus plantarum</i> LP115diamine oxidase (DAO)HT29 cellshistamine intoleranceprobiotics |
| spellingShingle | Gina Cavaliere Egidia Costanzi Beniamino Cenci-Goga Marco Misuraca Giovanna Traina Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism Biology <i>Lactiplantibacillus plantarum</i> LP115 diamine oxidase (DAO) HT29 cells histamine intolerance probiotics |
| title | Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism |
| title_full | Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism |
| title_fullStr | Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism |
| title_full_unstemmed | Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism |
| title_short | Potential Role of Probiotic Strain <i>Lactiplantibacillus plantarum</i> in Control of Histamine Metabolism |
| title_sort | potential role of probiotic strain i lactiplantibacillus plantarum i in control of histamine metabolism |
| topic | <i>Lactiplantibacillus plantarum</i> LP115 diamine oxidase (DAO) HT29 cells histamine intolerance probiotics |
| url | https://www.mdpi.com/2079-7737/14/6/734 |
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