Analgesic action of hexaazaisowurtzitane derivative in somatic pain models caused by TRPA1 and TRPV1 Ion channels activation

Analgesic action of hexaazaisowurtzitane derivative in somatic pain models caused by TRPA1 and TRPV1 Ion channels activation

The aim of this study was to assess the analgesic action of thiowurtzine in somatogenic nociception models by activation of TRPA1 and TRPV1 ion channels.Materials and methods. The object of the study is the compound 4-(3,4-dibromothiophenecarbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracycl...

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Bibliographic Details
Main Authors: S. G. Krylova, K. A. Lopatina, E. P. Zueva, E. A. Safonova, T. N. Povet’eva, Yu. V. Nesterova, O. G. Afanas’eva, P. V. Kul’pin, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2021-01-01
Series:Бюллетень сибирской медицины
Subjects:
hexaazaisowurtzitane
thiowurtzine
analgesic activity
somatogenic nociception
trp ion channels
formalin test
capsaicin
ketorolac
diclofenac
anti-inflammatory activity
Online Access:https://bulletin.ssmu.ru/jour/article/view/4158
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