Structural Characterization of 7-Chloro-4-(4-methyl-1-piperazinyl)quinoline Monohydrate
The crystal structure of the hydrated form of 7-chloro-4-(4-methyl-1-piperazinyl)quinoline (<b>BPIP</b>) was determined by single-crystal X-ray diffraction analysis. This study revealed a one-dimensional supramolecular network stabilized by hydrogen bonding interactions between <b>...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2025/2/M2016 |
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| Summary: | The crystal structure of the hydrated form of 7-chloro-4-(4-methyl-1-piperazinyl)quinoline (<b>BPIP</b>) was determined by single-crystal X-ray diffraction analysis. This study revealed a one-dimensional supramolecular network stabilized by hydrogen bonding interactions between <b>BPIP</b> and water molecules. This compound represents one-half of a piperaquine molecule, a member of the 4-aminoquinoline class of antimalarial treatments, currently employed as a partner agent in modern combination therapies. As a simplified structural analog, <b>BPIP</b> can serve as a critical model system for probing the intermolecular interactions, physicochemical properties, and structural behavior of the parent compound. As a result, conducting a thorough solid-state characterization of <b>BPIP</b> is critical for gaining insight into its physical properties and verifying the material’s identity and purity. |
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| ISSN: | 1422-8599 |