PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use
It is known that currently PARP inhibitors are actively used in the treatment of tumors of the female reproductive system. A large number of studies have been presented demonstrating the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. It was found that mutations...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-06-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/703 |
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| author | D. S. Dolgasheva A. M. Pevzner M. K. Ibragimova N. V. Litvyakov M. M. Tsyganov |
| author_facet | D. S. Dolgasheva A. M. Pevzner M. K. Ibragimova N. V. Litvyakov M. M. Tsyganov |
| author_sort | D. S. Dolgasheva |
| collection | DOAJ |
| description | It is known that currently PARP inhibitors are actively used in the treatment of tumors of the female reproductive system. A large number of studies have been presented demonstrating the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. It was found that mutations in the BRCA1 and BRCA2 genes are also characteristic of breast cancer (BC). However, PARP inhibitors are rarely used in clinical practice in the treatment of BC. So far, only olaparib has become the first PARP inhibitor approved for the treatment of metastatic BC. This review presents data over the past ten years showing the high efficiency of PARP inhibitors in the treatment of malignant neoplasms of the mammary gland. In 7 of 28 studies analyzed, positive results were achieved with combined treatment with chemotherapeutic drugs and PARP inhibitors. So, for example, in two studies in the treatment of BRCA-associated BC, the response to treatment in patients was 72.5–73.2 %. Thus, PARP inhibitors are of great interest and are of practical value in the treatment of patients with BC. |
| format | Article |
| id | doaj-art-801aef3c835e4a2ca686f70ad2a8960f |
| institution | Matheson Library |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2020-06-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-801aef3c835e4a2ca686f70ad2a8960f2025-08-04T14:33:41ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272020-06-01161556410.17650/1994-4098-2020-16-1-55-64638PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical useD. S. Dolgasheva0A. M. Pevzner1M. K. Ibragimova2N. V. Litvyakov3M. M. Tsyganov4Oncology Research Institute, Tomsk National Medical Research Center of the Russian Academy of Sciences; National Tomsk State Research UniversityOncology Research Institute, Tomsk National Medical Research Center of the Russian Academy of Sciences; National Tomsk State Research UniversityOncology Research Institute, Tomsk National Medical Research Center of the Russian Academy of SciencesOncology Research Institute, Tomsk National Medical Research Center of the Russian Academy of SciencesOncology Research Institute, Tomsk National Medical Research Center of the Russian Academy of SciencesIt is known that currently PARP inhibitors are actively used in the treatment of tumors of the female reproductive system. A large number of studies have been presented demonstrating the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. It was found that mutations in the BRCA1 and BRCA2 genes are also characteristic of breast cancer (BC). However, PARP inhibitors are rarely used in clinical practice in the treatment of BC. So far, only olaparib has become the first PARP inhibitor approved for the treatment of metastatic BC. This review presents data over the past ten years showing the high efficiency of PARP inhibitors in the treatment of malignant neoplasms of the mammary gland. In 7 of 28 studies analyzed, positive results were achieved with combined treatment with chemotherapeutic drugs and PARP inhibitors. So, for example, in two studies in the treatment of BRCA-associated BC, the response to treatment in patients was 72.5–73.2 %. Thus, PARP inhibitors are of great interest and are of practical value in the treatment of patients with BC.https://ojrs.abvpress.ru/ojrs/article/view/703breast cancerparp1inhibitorschemotherapytreatment effectprogression-free survival |
| spellingShingle | D. S. Dolgasheva A. M. Pevzner M. K. Ibragimova N. V. Litvyakov M. M. Tsyganov PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use Опухоли женской репродуктивной системы breast cancer parp1 inhibitors chemotherapy treatment effect progression-free survival |
| title | PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use |
| title_full | PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use |
| title_fullStr | PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use |
| title_full_unstemmed | PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use |
| title_short | PARP1 inhibitors in breast cancer therapy. Mechanism of action and clinical use |
| title_sort | parp1 inhibitors in breast cancer therapy mechanism of action and clinical use |
| topic | breast cancer parp1 inhibitors chemotherapy treatment effect progression-free survival |
| url | https://ojrs.abvpress.ru/ojrs/article/view/703 |
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