MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1
MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression. However, its role in hepatocellular carcinoma remains unknown. In this study, miR-590-3p level w...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695947 |
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| _version_ | 1839600621228916736 |
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| author | Xin Ge Liansheng Gong |
| author_facet | Xin Ge Liansheng Gong |
| author_sort | Xin Ge |
| collection | DOAJ |
| description | MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression. However, its role in hepatocellular carcinoma remains unknown. In this study, miR-590-3p level was measured, and clinicopathological features were determined in hepatocellular carcinoma tissues. The function of miR-590-3p was examined in vitro and in vivo. Real-time reverse transcription polymerase chain reaction analysis demonstrated downregulation of miR-590-3p in hepatocellular carcinoma tissues, and its downregulation was associated with a poor overall survival of hepatocellular carcinoma patients. Ectopic expression of miR-590-3p promoted growth of hepatocellular carcinoma cells, whereas its depletion inhibited cell growth. Transcriptional enhancer activator domain 1 was identified as a validated miR-590-3p target. Upregulation of transcriptional enhancer activator domain 1 was found in hepatocellular carcinoma tissues and inversely correlated with miR-590-3p. Our results indicate a tumor suppressor role of miR-590-3p in hepatocellular carcinoma through targeting transcriptional enhancer activator domain 1 and suggest its use in the diagnosis and prognosis of liver cancer. |
| format | Article |
| id | doaj-art-7f7eaecbb26e429e91e4d25d835c7a7c |
| institution | Matheson Library |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-7f7eaecbb26e429e91e4d25d835c7a7c2025-08-02T12:13:12ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695947MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1Xin GeLiansheng GongMicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression. However, its role in hepatocellular carcinoma remains unknown. In this study, miR-590-3p level was measured, and clinicopathological features were determined in hepatocellular carcinoma tissues. The function of miR-590-3p was examined in vitro and in vivo. Real-time reverse transcription polymerase chain reaction analysis demonstrated downregulation of miR-590-3p in hepatocellular carcinoma tissues, and its downregulation was associated with a poor overall survival of hepatocellular carcinoma patients. Ectopic expression of miR-590-3p promoted growth of hepatocellular carcinoma cells, whereas its depletion inhibited cell growth. Transcriptional enhancer activator domain 1 was identified as a validated miR-590-3p target. Upregulation of transcriptional enhancer activator domain 1 was found in hepatocellular carcinoma tissues and inversely correlated with miR-590-3p. Our results indicate a tumor suppressor role of miR-590-3p in hepatocellular carcinoma through targeting transcriptional enhancer activator domain 1 and suggest its use in the diagnosis and prognosis of liver cancer.https://doi.org/10.1177/1010428317695947 |
| spellingShingle | Xin Ge Liansheng Gong MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 Tumor Biology |
| title | MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 |
| title_full | MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 |
| title_fullStr | MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 |
| title_full_unstemmed | MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 |
| title_short | MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 |
| title_sort | mir 590 3p suppresses hepatocellular carcinoma growth by targeting tead1 |
| url | https://doi.org/10.1177/1010428317695947 |
| work_keys_str_mv | AT xinge mir5903psuppresseshepatocellularcarcinomagrowthbytargetingtead1 AT lianshenggong mir5903psuppresseshepatocellularcarcinomagrowthbytargetingtead1 |