Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis
Abstract Background/Aims Given that acute bacterial meningitis (ABM), as community‐acquired meningitis, is considered a life‐threatening medical emergency, early diagnosis and immediate onset of antibiotic therapy are of great importance. Here, we aimed to compare both the laboratory and glucometer...
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Wiley
2025-07-01
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| Series: | Journal of General and Family Medicine |
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| Online Access: | https://doi.org/10.1002/jgf2.70004 |
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| author | Nasrin Khodashenas Rouzbeh Rajaei Ghafouri Asghar Jafari Rouhi Moloud Balafar |
| author_facet | Nasrin Khodashenas Rouzbeh Rajaei Ghafouri Asghar Jafari Rouhi Moloud Balafar |
| author_sort | Nasrin Khodashenas |
| collection | DOAJ |
| description | Abstract Background/Aims Given that acute bacterial meningitis (ABM), as community‐acquired meningitis, is considered a life‐threatening medical emergency, early diagnosis and immediate onset of antibiotic therapy are of great importance. Here, we aimed to compare both the laboratory and glucometer assessment of cerebrospinal fluid (CSF)/serum glucose ratio in patients with suspected ABM. In addition, the prognostic value of the CSF/serum glucose ratio on the mortality rate was also evaluated. Methods In this cross‐sectional, single‐center study, all demographic and clinical characteristics of patients who attended the emergency department were evaluated. A total of 200 patients with clinical suspicion of ABM underwent lumbar puncture (LP) and were simultaneously recruited for CSF and serum glucose measurement using both laboratory tests and a point‐of‐care glucometer device. Data analysis was performed using SPSS ver. 20.0. Results Out of 200 suspected subjects with a mean age of 52.66 ± 6.64 years (male = 113, 56.5%), 23 patients (11.5%) were identified with confirmed ABM. The study findings showed a close correlation between the laboratory and glucometer‐measured CSF/serum glucose ratio. The sensitivity and specificity of the glucose ratio measured by the laboratory test were 91.3% and 86.4%, respectively. A similar result was also observed by glucometer measurement (Sensitivity: 91.3%, Specificity: 89.3%, p < 0.001). However, the mean time needed for CSF glucose measurement was significantly longer in the laboratory method compared to the glucometer‐based assessment (p < 0.0001). Notably, the CSF/serum glucose ratio was considerably lower in deceased patients (n = 9, p < 0.05). Conclusion Despite the similar accuracy of the CSF/serum glucose ratio using either a laboratory test or glucometer for ABM diagnosis, the present study highlighted that the laboratory turnaround time was significantly improved using a glucometer, which could be considered a reliable aid to the prognosis of mortality. |
| format | Article |
| id | doaj-art-7f7d7cccb5bd4d4c981b55ebd06f8170 |
| institution | Matheson Library |
| issn | 2189-7948 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Journal of General and Family Medicine |
| spelling | doaj-art-7f7d7cccb5bd4d4c981b55ebd06f81702025-07-09T05:04:39ZengWileyJournal of General and Family Medicine2189-79482025-07-0126430531110.1002/jgf2.70004Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitisNasrin Khodashenas0Rouzbeh Rajaei Ghafouri1Asghar Jafari Rouhi2Moloud Balafar3Emergency and Trauma Care Research Center Tabriz University of Medical Sciences Tabriz IranEmergency and Trauma Care Research Center Tabriz University of Medical Sciences Tabriz IranEmergency and Trauma Care Research Center Tabriz University of Medical Sciences Tabriz IranEmergency and Trauma Care Research Center Tabriz University of Medical Sciences Tabriz IranAbstract Background/Aims Given that acute bacterial meningitis (ABM), as community‐acquired meningitis, is considered a life‐threatening medical emergency, early diagnosis and immediate onset of antibiotic therapy are of great importance. Here, we aimed to compare both the laboratory and glucometer assessment of cerebrospinal fluid (CSF)/serum glucose ratio in patients with suspected ABM. In addition, the prognostic value of the CSF/serum glucose ratio on the mortality rate was also evaluated. Methods In this cross‐sectional, single‐center study, all demographic and clinical characteristics of patients who attended the emergency department were evaluated. A total of 200 patients with clinical suspicion of ABM underwent lumbar puncture (LP) and were simultaneously recruited for CSF and serum glucose measurement using both laboratory tests and a point‐of‐care glucometer device. Data analysis was performed using SPSS ver. 20.0. Results Out of 200 suspected subjects with a mean age of 52.66 ± 6.64 years (male = 113, 56.5%), 23 patients (11.5%) were identified with confirmed ABM. The study findings showed a close correlation between the laboratory and glucometer‐measured CSF/serum glucose ratio. The sensitivity and specificity of the glucose ratio measured by the laboratory test were 91.3% and 86.4%, respectively. A similar result was also observed by glucometer measurement (Sensitivity: 91.3%, Specificity: 89.3%, p < 0.001). However, the mean time needed for CSF glucose measurement was significantly longer in the laboratory method compared to the glucometer‐based assessment (p < 0.0001). Notably, the CSF/serum glucose ratio was considerably lower in deceased patients (n = 9, p < 0.05). Conclusion Despite the similar accuracy of the CSF/serum glucose ratio using either a laboratory test or glucometer for ABM diagnosis, the present study highlighted that the laboratory turnaround time was significantly improved using a glucometer, which could be considered a reliable aid to the prognosis of mortality.https://doi.org/10.1002/jgf2.70004cerebrospinal fluidglucosemeningitis bacterialmortalityspinal puncture |
| spellingShingle | Nasrin Khodashenas Rouzbeh Rajaei Ghafouri Asghar Jafari Rouhi Moloud Balafar Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis Journal of General and Family Medicine cerebrospinal fluid glucose meningitis bacterial mortality spinal puncture |
| title | Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis |
| title_full | Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis |
| title_fullStr | Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis |
| title_full_unstemmed | Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis |
| title_short | Early detection of cerebrospinal fluid/serum glucose ratio: A promising value for mortality prognosis in patients with acute bacterial meningitis |
| title_sort | early detection of cerebrospinal fluid serum glucose ratio a promising value for mortality prognosis in patients with acute bacterial meningitis |
| topic | cerebrospinal fluid glucose meningitis bacterial mortality spinal puncture |
| url | https://doi.org/10.1002/jgf2.70004 |
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