Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer.

Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer.

Common genetic variants associated with lung cancer have been well studied in the past decade. However, only 12.3% heritability has been explained by these variants. In this study, we investigate the contribution of rare variants (RVs) (minor allele frequency <0.01) to lung cancer through two lar...

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Main Authors: Jingxiong Xu, Wei Xu, Jiyeon Choi, Yonathan Brhane, David C Christiani, Jui Kothari, James McKay, John K Field, Michael P A Davies, Geoffrey Liu, Christopher I Amos, Rayjean J Hung, Laurent Briollais
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010902&type=printable
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