Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage
Background/Aims HDL cholesterol (HDL-C) may have anti-tumor effects; however, the effects remain unclear. Thus, this study aimed to investigate sex- and tumor stage-specific association of hyperglycemia and HDL-C with gastric cancer. Materials and Methods We used the National Health Insurance Servic...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2022-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2022-0023.pdf |
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| author | Su Youn Nam Jihyeon Jeong Won Kee Lee Seong Woo Jeon |
| author_facet | Su Youn Nam Jihyeon Jeong Won Kee Lee Seong Woo Jeon |
| author_sort | Su Youn Nam |
| collection | DOAJ |
| description | Background/Aims HDL cholesterol (HDL-C) may have anti-tumor effects; however, the effects remain unclear. Thus, this study aimed to investigate sex- and tumor stage-specific association of hyperglycemia and HDL-C with gastric cancer. Materials and Methods We used the National Health Insurance Service data. All participants underwent gastric cancer screening between January and December 2011. Hyperglycemia and HDL-C levels were categorized according to the World Health Organization guideline and Adult Treatment Panel III. Adjusted regression analysis was performed using ORs and 95% CIs. Results Gastric cancer was detected in 10,417 of 5.49 million individuals (2.43 million men). Hyperglycemia (OR, 1.28; 95% CI, 1.20~1.36) and low HDL-C levels (OR, 1.41; 95% CI, 1.35~1.48) were associated with gastric cancer. In the sub-analysis by sex, hyperglycemia (≥126 mg/dL) was associated with gastric cancer in both men (OR, 1.26; 95% CI, 1.18~1.36) and women (OR, 1.32; 95% CI, 1.17~1.49). Low HDL-C levels were associated with gastric cancer in both men (OR, 1.49; 95% CI, 1.40~1.58) and women (OR, 1.32; 95% CI, 1.27~1.42). In the sub-analysis by tumor stage, hyperglycemia was associated with both early (OR, 1.14; 95% CI, 1.08~1.20) and advanced gastric cancer (OR, 1.39; 95% CI, 1.26~1.55). Low HDL-C levels were also associated with early (OR, 1.34; 95% CI, 1.27~1.41) and advanced gastric cancer (OR, 1.92; 95% CI, 1.74~2.13). Conclusions Hyperglycemia and low HDL-C levels are consistently associated with gastric cancer regardless of sex or tumor stage. |
| format | Article |
| id | doaj-art-7f3b50d0dcce4da5b17f8f317c78401d |
| institution | Matheson Library |
| issn | 1738-3331 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-7f3b50d0dcce4da5b17f8f317c78401d2025-08-02T12:11:56ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312022-09-0122322223010.7704/kjhugr.2022.0023743Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor StageSu Youn Nam0Jihyeon Jeong1Won Kee Lee2Seong Woo Jeon3 Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea Department of Statistics, Kyungpook National University, Daegu, Korea Biostatistics, Medical Research Collaboration Center, Kyunpook National University Hospital, Daegu, Korea Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, KoreaBackground/Aims HDL cholesterol (HDL-C) may have anti-tumor effects; however, the effects remain unclear. Thus, this study aimed to investigate sex- and tumor stage-specific association of hyperglycemia and HDL-C with gastric cancer. Materials and Methods We used the National Health Insurance Service data. All participants underwent gastric cancer screening between January and December 2011. Hyperglycemia and HDL-C levels were categorized according to the World Health Organization guideline and Adult Treatment Panel III. Adjusted regression analysis was performed using ORs and 95% CIs. Results Gastric cancer was detected in 10,417 of 5.49 million individuals (2.43 million men). Hyperglycemia (OR, 1.28; 95% CI, 1.20~1.36) and low HDL-C levels (OR, 1.41; 95% CI, 1.35~1.48) were associated with gastric cancer. In the sub-analysis by sex, hyperglycemia (≥126 mg/dL) was associated with gastric cancer in both men (OR, 1.26; 95% CI, 1.18~1.36) and women (OR, 1.32; 95% CI, 1.17~1.49). Low HDL-C levels were associated with gastric cancer in both men (OR, 1.49; 95% CI, 1.40~1.58) and women (OR, 1.32; 95% CI, 1.27~1.42). In the sub-analysis by tumor stage, hyperglycemia was associated with both early (OR, 1.14; 95% CI, 1.08~1.20) and advanced gastric cancer (OR, 1.39; 95% CI, 1.26~1.55). Low HDL-C levels were also associated with early (OR, 1.34; 95% CI, 1.27~1.41) and advanced gastric cancer (OR, 1.92; 95% CI, 1.74~2.13). Conclusions Hyperglycemia and low HDL-C levels are consistently associated with gastric cancer regardless of sex or tumor stage.http://www.helicojournal.org/upload/pdf/kjhugr-2022-0023.pdfbody mass indexstomach neoplasmshigh density lipoproteinsex |
| spellingShingle | Su Youn Nam Jihyeon Jeong Won Kee Lee Seong Woo Jeon Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage The Korean Journal of Helicobacter and Upper Gastrointestinal Research body mass index stomach neoplasms high density lipoprotein sex |
| title | Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage |
| title_full | Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage |
| title_fullStr | Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage |
| title_full_unstemmed | Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage |
| title_short | Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage |
| title_sort | low serum level of high density lipoprotein cholesterol is associated with gastric cancer regardless of sex and tumor stage |
| topic | body mass index stomach neoplasms high density lipoprotein sex |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2022-0023.pdf |
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