Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report
Introduction. Historically, HIV-infected patients were denied liver transplantation due to concerns about poorer outcomes compared to the non-infected population. Due to advances in antiretroviral therapy and improved understanding of the immunological status of these patients, transplantation has b...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2025-06-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/1265 |
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| author | B. I. Kazymov K. F. Alekberov M. S. Yadrikhinskaya A. D. Kuznetsova A. O. Petrova S. Yu. Shemakin |
| author_facet | B. I. Kazymov K. F. Alekberov M. S. Yadrikhinskaya A. D. Kuznetsova A. O. Petrova S. Yu. Shemakin |
| author_sort | B. I. Kazymov |
| collection | DOAJ |
| description | Introduction. Historically, HIV-infected patients were denied liver transplantation due to concerns about poorer outcomes compared to the non-infected population. Due to advances in antiretroviral therapy and improved understanding of the immunological status of these patients, transplantation has become a viable treatment option.Case Description. This report describes a 56-year-old HIV-positive man with multiple comorbidities who underwent liver transplantation for end-stage liver disease due to chronic hepatitis B. The early post-transplantation period was complicated by severe sepsis, multiple organ failure, and graft dysfunction.Treatment Methods. Comprehensive therapy included prolonged vasopressor support, renal replacement therapy, multiple blood transfusions, and targeted antimicrobial therapy.Results. The patient was successfully treated and discharged in stable condition with a functioning graft.Conclusion. This case demonstrates that even severe infectious complications after liver transplantation in polymorbid HIV-positive patients can be successfully treated with appropriate multidisciplinary intensive care. |
| format | Article |
| id | doaj-art-7ec2dfbcc61e4de1a1fad3f7a9a5c7f8 |
| institution | Matheson Library |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-7ec2dfbcc61e4de1a1fad3f7a9a5c7f82025-08-03T13:33:59ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792025-06-0115217217810.20340/vmi-rvz.2025.2.CASE.3767Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case reportB. I. Kazymov0K. F. Alekberov1M. S. Yadrikhinskaya2A. D. Kuznetsova3A. O. Petrova4S. Yu. Shemakin5N.V. Sklifosovsky Research Institute of Emergency Medicine; Moscow Medical University "Reaviz"N.V. Sklifosovsky Research Institute of Emergency MedicineMoscow City Center for AIDS Prevention and ControlRyazan State Medical University named after I.P. PavlovSamara State Medical UniversityN.V. Sklifosovsky Research Institute of Emergency MedicineIntroduction. Historically, HIV-infected patients were denied liver transplantation due to concerns about poorer outcomes compared to the non-infected population. Due to advances in antiretroviral therapy and improved understanding of the immunological status of these patients, transplantation has become a viable treatment option.Case Description. This report describes a 56-year-old HIV-positive man with multiple comorbidities who underwent liver transplantation for end-stage liver disease due to chronic hepatitis B. The early post-transplantation period was complicated by severe sepsis, multiple organ failure, and graft dysfunction.Treatment Methods. Comprehensive therapy included prolonged vasopressor support, renal replacement therapy, multiple blood transfusions, and targeted antimicrobial therapy.Results. The patient was successfully treated and discharged in stable condition with a functioning graft.Conclusion. This case demonstrates that even severe infectious complications after liver transplantation in polymorbid HIV-positive patients can be successfully treated with appropriate multidisciplinary intensive care.https://vestnik.reaviz.ru/jour/article/view/1265hiv infection [d015658]liver transplantation [d016031]sepsis [d018805]multiple organ failure [d009102]immunosuppressive therapy [d007166]antiretroviral therapy [d044966]postoperative complications [d011183]hepatitis b [d006509]critical care [d003422]hemodiafiltration [d006435] |
| spellingShingle | B. I. Kazymov K. F. Alekberov M. S. Yadrikhinskaya A. D. Kuznetsova A. O. Petrova S. Yu. Shemakin Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье hiv infection [d015658] liver transplantation [d016031] sepsis [d018805] multiple organ failure [d009102] immunosuppressive therapy [d007166] antiretroviral therapy [d044966] postoperative complications [d011183] hepatitis b [d006509] critical care [d003422] hemodiafiltration [d006435] |
| title | Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report |
| title_full | Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report |
| title_fullStr | Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report |
| title_full_unstemmed | Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report |
| title_short | Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report |
| title_sort | successful management of sepsis following liver transplantation in an hiv positive patient with multiple comorbidities a case report |
| topic | hiv infection [d015658] liver transplantation [d016031] sepsis [d018805] multiple organ failure [d009102] immunosuppressive therapy [d007166] antiretroviral therapy [d044966] postoperative complications [d011183] hepatitis b [d006509] critical care [d003422] hemodiafiltration [d006435] |
| url | https://vestnik.reaviz.ru/jour/article/view/1265 |
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