METTL3通过m6A甲基化修饰影响葡萄膜黑色素瘤细胞增殖、迁移和侵袭
目的探讨<italic>METTL3</italic>对葡萄膜黑色素瘤细胞的恶性生物学行为影响，并验证其是否和N6-甲基腺苷（m6A）甲基化相关。方法用慢病毒转染构建敲低、过表达<italic>METTL3</italic>以及点突变m6A相关催化位点的葡萄膜黑色素瘤细胞模型，通过Transwell了解细胞迁移、侵袭情况，利用CCK-8检测细胞增殖能力，流式细胞仪分析细胞凋亡及周期的变化。结果敲低<italic>METTL3</italic>的C918和MUM-2B细胞在增殖、迁移和侵袭能力方面明显下降（<itali...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Chinese |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2025-07-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0409/ |
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