Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients
Sickle cell disease (SCD) comprises an inherited blood disorder that is life long and affects many people globally. In spite of the development in treatment, SCA is a considerable cause of mortality and morbidity. The present study tries to assess the role of leukocytes represented by β integrin(CD...
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University of Baghdad, College of Science for Women
2023-02-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6601 |
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| author | Maha K. Al-Mishrey |
| author_facet | Maha K. Al-Mishrey |
| author_sort | Maha K. Al-Mishrey |
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Sickle cell disease (SCD) comprises an inherited blood disorder that is life long and affects many people globally. In spite of the development in treatment, SCA is a considerable cause of mortality and morbidity. The present study tries to assess the role of leukocytes represented by β integrin(CD18) and platelets and their productivity in the pathogenicity of disease during the steady state and crisis in comparison with the healthy as-control group, SCD patients (15) enrolled during crisis and steady state (follow up) showed a significant increase in leukocytes and platelets cells productivity during crisis when compared to the steady state and in the steady state when compared to the healthy control group . In this study, SCD pathophysiology in steady state and crisis affected by the platelets account and leukocyte activation triggered by inflammatory factors and reflex on the adherence and attachment between cells and blood vessel led to vascular occlusion (VOC).
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| format | Article |
| id | doaj-art-7e7fc9ca314e48c1b809fc0ff369561b |
| institution | Matheson Library |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-7e7fc9ca314e48c1b809fc0ff369561b2025-08-02T12:07:41ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862023-02-0120110.21123/bsj.2022.6601Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate PatientsMaha K. Al-Mishrey0Department of Biology, College of Science, University of Basrah, Basrah Iraq. Sickle cell disease (SCD) comprises an inherited blood disorder that is life long and affects many people globally. In spite of the development in treatment, SCA is a considerable cause of mortality and morbidity. The present study tries to assess the role of leukocytes represented by β integrin(CD18) and platelets and their productivity in the pathogenicity of disease during the steady state and crisis in comparison with the healthy as-control group, SCD patients (15) enrolled during crisis and steady state (follow up) showed a significant increase in leukocytes and platelets cells productivity during crisis when compared to the steady state and in the steady state when compared to the healthy control group . In this study, SCD pathophysiology in steady state and crisis affected by the platelets account and leukocyte activation triggered by inflammatory factors and reflex on the adherence and attachment between cells and blood vessel led to vascular occlusion (VOC). https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6601β integrin(CD18), pathogenicity, Platelets, Sickle cell disease |
| spellingShingle | Maha K. Al-Mishrey Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients مجلة بغداد للعلوم β integrin(CD18), pathogenicity, Platelets, Sickle cell disease |
| title | Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients |
| title_full | Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients |
| title_fullStr | Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients |
| title_full_unstemmed | Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients |
| title_short | Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients |
| title_sort | evaluation of beta 2 integrin and platelets roles in sickle cell disease pathogenicity in basrah governorate patients |
| topic | β integrin(CD18), pathogenicity, Platelets, Sickle cell disease |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6601 |
| work_keys_str_mv | AT mahakalmishrey evaluationofbeta2integrinandplateletsrolesinsicklecelldiseasepathogenicityinbasrahgovernoratepatients |