Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease

Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease

Nitrate, which maintains hemostasis in systemic circulation, is obtained from nitrate-rich vegetables, concentrated, reabsorbed by the salivary glands, and reduced to nitrite and nitric oxide (NO•). The bioavailability of nitrate and nitrite depends on unique nitrate reductases present in specific b...

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Bibliographic Details
Main Authors: Zi Yang, Conglin Du, Zhichao Chang, Yang Yang, Liang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
nitric oxide
nitrate
nitrate reductase
oral microbiome
gut microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1612223/full
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