Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment
The article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the administered drug doses have been studied. Clozapin...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2018-02-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/107 |
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| _version_ | 1839583168355631104 |
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| author | N. V. Baymeeva L. M. Krasnykh I. I. Miroshnichenko |
| author_facet | N. V. Baymeeva L. M. Krasnykh I. I. Miroshnichenko |
| author_sort | N. V. Baymeeva |
| collection | DOAJ |
| description | The article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the administered drug doses have been studied. Clozapine and norclozapine assay in human blood has been performed by high performance liquid chromatography with mass spectrometric detection. Monitoring and subsequent data analysis has been supported with necessary clinical information in the form of special requests - TDM cards. The obtained data on concentration levels have been arranged as follows: 38.64 % within therapeutic range, 38.64 % within subtherapeutic range ( |
| format | Article |
| id | doaj-art-7d82c416bb8341c99a8c46f8ee64dd1a |
| institution | Matheson Library |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj-art-7d82c416bb8341c99a8c46f8ee64dd1a2025-08-03T19:56:42ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532018-02-01045357105Monitoring of clozapine and norclozapine concentrations in schizophrenia treatmentN. V. Baymeeva0L. M. Krasnykh1I. I. Miroshnichenko2Scientific Center of Mental HealthScientific Centre for Expert Evaluation of Medicinal ProductsScientific Center of Mental HealthThe article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the administered drug doses have been studied. Clozapine and norclozapine assay in human blood has been performed by high performance liquid chromatography with mass spectrometric detection. Monitoring and subsequent data analysis has been supported with necessary clinical information in the form of special requests - TDM cards. The obtained data on concentration levels have been arranged as follows: 38.64 % within therapeutic range, 38.64 % within subtherapeutic range (https://www.vedomostincesmp.ru/jour/article/view/107терапевтический лекарственный мониторингшизофрениятандемная хроматомасс-спектрометрияклозапиннорклозапинtdmschizophrenialiquid chromatography tandem-mass spectrometryclozapinenorclozapine |
| spellingShingle | N. V. Baymeeva L. M. Krasnykh I. I. Miroshnichenko Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment Регуляторные исследования и экспертиза лекарственных средств терапевтический лекарственный мониторинг шизофрения тандемная хроматомасс-спектрометрия клозапин норклозапин tdm schizophrenia liquid chromatography tandem-mass spectrometry clozapine norclozapine |
| title | Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| title_full | Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| title_fullStr | Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| title_full_unstemmed | Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| title_short | Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| title_sort | monitoring of clozapine and norclozapine concentrations in schizophrenia treatment |
| topic | терапевтический лекарственный мониторинг шизофрения тандемная хроматомасс-спектрометрия клозапин норклозапин tdm schizophrenia liquid chromatography tandem-mass spectrometry clozapine norclozapine |
| url | https://www.vedomostincesmp.ru/jour/article/view/107 |
| work_keys_str_mv | AT nvbaymeeva monitoringofclozapineandnorclozapineconcentrationsinschizophreniatreatment AT lmkrasnykh monitoringofclozapineandnorclozapineconcentrationsinschizophreniatreatment AT iimiroshnichenko monitoringofclozapineandnorclozapineconcentrationsinschizophreniatreatment |