Sarcopenia: pathogenesis and diagnosis
Increase in life expectancy is among the most significant achievements of modern medicine. Currently, the majority of patients are elderly, being characterised by multimorbidity and frailty. Sarcopenia, a progressive and generalized loss of skeletal muscle mass and strength, is associated with a red...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2019-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/196 |
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| author | I. I. Grigorieva T. A. Raskina M. V. Letaeva O. S. Malyshenko Yu. V. Averkieva V. L. Masenko A. N. Kokov |
| author_facet | I. I. Grigorieva T. A. Raskina M. V. Letaeva O. S. Malyshenko Yu. V. Averkieva V. L. Masenko A. N. Kokov |
| author_sort | I. I. Grigorieva |
| collection | DOAJ |
| description | Increase in life expectancy is among the most significant achievements of modern medicine. Currently, the majority of patients are elderly, being characterised by multimorbidity and frailty. Sarcopenia, a progressive and generalized loss of skeletal muscle mass and strength, is associated with a reduced quality of life and high risk of adverse outcomes including disability and death in these patients. Age-related neuromuscular degeneration, decline of circulating anabolic hormones, chronic inflammation and oxidative stress considerably affect the development of sarcopenia. In addition, low intake of proteins and carbohydrates along with a decrease in physical activity also affect muscular homeostasis. Being combined with obesity, osteopenia/osteoporosis, and vitamin D deficiency, sarcopenia worsens the prognosis of the patient in terms of life expectancy. In this review, we discuss the current advances in epidemiology, pathophysiology, and diagnosis of sarcopenia. |
| format | Article |
| id | doaj-art-7d098eaa3c0b40f2a926a3d7c0c2f2d1 |
| institution | Matheson Library |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-7d098eaa3c0b40f2a926a3d7c0c2f2d12025-08-03T12:59:24ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412019-12-014410511610.23946/2500-0764-2019-4-4-105-116182Sarcopenia: pathogenesis and diagnosisI. I. Grigorieva0T. A. Raskina1M. V. Letaeva2O. S. Malyshenko3Yu. V. Averkieva4V. L. Masenko5A. N. Kokov6Kemerovo State Medical UniversityKemerovo State Medical UniversityKemerovo State Medical UniversityKemerovo State Medical UniversityKemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular DiseaseResearch Institute for Complex Issues of Cardiovascular DiseaseIncrease in life expectancy is among the most significant achievements of modern medicine. Currently, the majority of patients are elderly, being characterised by multimorbidity and frailty. Sarcopenia, a progressive and generalized loss of skeletal muscle mass and strength, is associated with a reduced quality of life and high risk of adverse outcomes including disability and death in these patients. Age-related neuromuscular degeneration, decline of circulating anabolic hormones, chronic inflammation and oxidative stress considerably affect the development of sarcopenia. In addition, low intake of proteins and carbohydrates along with a decrease in physical activity also affect muscular homeostasis. Being combined with obesity, osteopenia/osteoporosis, and vitamin D deficiency, sarcopenia worsens the prognosis of the patient in terms of life expectancy. In this review, we discuss the current advances in epidemiology, pathophysiology, and diagnosis of sarcopenia.https://fcm.kemsmu.ru/jour/article/view/196sarcopeniaosteoporosisosteosarcopeniageriatric syndrome |
| spellingShingle | I. I. Grigorieva T. A. Raskina M. V. Letaeva O. S. Malyshenko Yu. V. Averkieva V. L. Masenko A. N. Kokov Sarcopenia: pathogenesis and diagnosis Фундаментальная и клиническая медицина sarcopenia osteoporosis osteosarcopenia geriatric syndrome |
| title | Sarcopenia: pathogenesis and diagnosis |
| title_full | Sarcopenia: pathogenesis and diagnosis |
| title_fullStr | Sarcopenia: pathogenesis and diagnosis |
| title_full_unstemmed | Sarcopenia: pathogenesis and diagnosis |
| title_short | Sarcopenia: pathogenesis and diagnosis |
| title_sort | sarcopenia pathogenesis and diagnosis |
| topic | sarcopenia osteoporosis osteosarcopenia geriatric syndrome |
| url | https://fcm.kemsmu.ru/jour/article/view/196 |
| work_keys_str_mv | AT iigrigorieva sarcopeniapathogenesisanddiagnosis AT taraskina sarcopeniapathogenesisanddiagnosis AT mvletaeva sarcopeniapathogenesisanddiagnosis AT osmalyshenko sarcopeniapathogenesisanddiagnosis AT yuvaverkieva sarcopeniapathogenesisanddiagnosis AT vlmasenko sarcopeniapathogenesisanddiagnosis AT ankokov sarcopeniapathogenesisanddiagnosis |