Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under...

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Bibliographic Details
Main Authors: Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Éva Borbély, Valéria Tékus, Bálint Botz, Kitti Rusznák, Anett Futácsi, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritic pain
analgesic drug development
semicarbazide-sensitive amine oxidase
amine oxidase copper containing 3
vascular adhesion protein 1
transient receptor potential vanilloid 1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1377081/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1377081/full

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