Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection

Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection

Background & Aims: Stem cell-derived hepatocyte-like cells (HLCs) are an in vitro model of hepatocytes reproducing mature hepatic functions. However, heterogeneous or imperfect differentiation may limit their biological relevance. HLCs are susceptible to all primary hepatitis viruses, includ...

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Bibliographic Details
Main Authors: Frauke Lange, Jonathan Garn, Matthias Bruhn, Thomas Pietschmann, Arnaud Carpentier
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHEP Reports
Subjects:
Single-cell RNA sequencing
Stem cell-derived hepatocytes
HLCs
Hepatitis delta
Innate immunity
Restriction factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001065
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