Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments

Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments

BackgroundSepsis is a condition with high mortality and multiple organ dysfunction, undergoing complex pathogenesis and limited treatment options. This study aims to uncover new therapeutic targets for sepsisMethodsThree independent transcriptomic datasets from sepsis patients in the GEO database we...

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Bibliographic Details
Main Authors: Meng-Qin Pei, Yan-Ling Lin, Li-Ming Xu, Yu-Shen Yang, Zhen-Dong Sun, Ya-Fen Zeng, Gui-Dan Wang, He-Fan He, Li-Ying Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SEMA4A
sepsis
Mendelian randomization
transcriptomics
single-cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1606509/full
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