The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens
This study was designed to identify molecular markers single nucleotide polymorphisms (SNPs) of MHC B-F gene and SPOCK1) associated with Salmonella pullorum disease susceptibility/resistance. A two-stage case-control association study was used. In the first study, a small population comprising 401 P...
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KeAi Communications Co., Ltd.
2016-08-01
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| Series: | Journal of Integrative Agriculture |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095311915613132 |
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| author | Ze-tang ZHANG Jian-kang GAN Wen-wu ZHANG De-xiang ZHANG Xi-quan ZHANG Qing-bin LUO |
| author_facet | Ze-tang ZHANG Jian-kang GAN Wen-wu ZHANG De-xiang ZHANG Xi-quan ZHANG Qing-bin LUO |
| author_sort | Ze-tang ZHANG |
| collection | DOAJ |
| description | This study was designed to identify molecular markers single nucleotide polymorphisms (SNPs) of MHC B-F gene and SPOCK1) associated with Salmonella pullorum disease susceptibility/resistance. A two-stage case-control association study was used. In the first study, a small population comprising 401 Partridge chickens (201 cases and 200 controls) was used, and a total of 118 SNPs genotyped. In the second study, a bigger population comprising 1 075 Partridge chickens (527 cases and 548 controls) was used, and SNPs with significant effect determined in the first study were further analysed. In the first study, 8 SNPs were significantly associated with S. Pullorum disease susceptibility/resistance, however, after further analysis, only the SNPs rs15001532 and C.513A>T were found to be significantly associated with S. Pullorum disease susceptibility/resistance. The relative risk test demonstrated that the AA genotype of rs15001532 resulted in a higher risk of S. Pullorum infection, whereas birds with the TT genotype of C.513A>T were more susceptible to S. Pullorum infection. This research was based on the researches on human complex diseases. With help of these train of thoughts, some common animal diseases can be studied effectively and the process of candidate gene research for animal disease can be improved. |
| format | Article |
| id | doaj-art-7c2e8ce09ed94bb4a251af1e7f7c7d2d |
| institution | Matheson Library |
| issn | 2095-3119 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Integrative Agriculture |
| spelling | doaj-art-7c2e8ce09ed94bb4a251af1e7f7c7d2d2025-08-02T11:54:13ZengKeAi Communications Co., Ltd.Journal of Integrative Agriculture2095-31192016-08-0115818561862The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickensZe-tang ZHANG0Jian-kang GAN1Wen-wu ZHANG2De-xiang ZHANG3Xi-quan ZHANG4Qing-bin LUO5College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. China; ZHANG Ze-tangCollege of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. China; Xinguang Agriculture & Animal Husbandry Co., Ltd., Foshan 528500, P.R. ChinaCollege of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. ChinaCollege of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. ChinaCollege of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. ChinaCollege of Animal Science, South China Agricultural University, Guangzhou 510642, P.R. China; Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, P.R. China; Correspondence LUO Qing-bin, Tel: +86-20-85285702This study was designed to identify molecular markers single nucleotide polymorphisms (SNPs) of MHC B-F gene and SPOCK1) associated with Salmonella pullorum disease susceptibility/resistance. A two-stage case-control association study was used. In the first study, a small population comprising 401 Partridge chickens (201 cases and 200 controls) was used, and a total of 118 SNPs genotyped. In the second study, a bigger population comprising 1 075 Partridge chickens (527 cases and 548 controls) was used, and SNPs with significant effect determined in the first study were further analysed. In the first study, 8 SNPs were significantly associated with S. Pullorum disease susceptibility/resistance, however, after further analysis, only the SNPs rs15001532 and C.513A>T were found to be significantly associated with S. Pullorum disease susceptibility/resistance. The relative risk test demonstrated that the AA genotype of rs15001532 resulted in a higher risk of S. Pullorum infection, whereas birds with the TT genotype of C.513A>T were more susceptible to S. Pullorum infection. This research was based on the researches on human complex diseases. With help of these train of thoughts, some common animal diseases can be studied effectively and the process of candidate gene research for animal disease can be improved.http://www.sciencedirect.com/science/article/pii/S2095311915613132MHC B-F geneSPOCK1 geneSNPsSalmonella pullorum,partridge chicken |
| spellingShingle | Ze-tang ZHANG Jian-kang GAN Wen-wu ZHANG De-xiang ZHANG Xi-quan ZHANG Qing-bin LUO The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens Journal of Integrative Agriculture MHC B-F gene SPOCK1 gene SNPs Salmonella pullorum, partridge chicken |
| title | The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens |
| title_full | The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens |
| title_fullStr | The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens |
| title_full_unstemmed | The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens |
| title_short | The SNPs C.513A>T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens |
| title_sort | snps c 513a t in the mhc b f gene and rs15001532 in the spock1 gene are associated with salmonella pullorum disease resistance in chickens |
| topic | MHC B-F gene SPOCK1 gene SNPs Salmonella pullorum, partridge chicken |
| url | http://www.sciencedirect.com/science/article/pii/S2095311915613132 |
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