New aspects of the influence of immunity and microbiome on heart transplant rejection
Currently, heart transplantation is the key treatment for patients with end-stage heart failure. At the same time, the immunopathogenesis of chronic allograft rejection, which is a key factor in the long-term outcome, is still poorly understood, which, in turn, explains the absence of effective non-...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2022-09-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4806 |
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| Summary: | Currently, heart transplantation is the key treatment for patients with end-stage heart failure. At the same time, the immunopathogenesis of chronic allograft rejection, which is a key factor in the long-term outcome, is still poorly understood, which, in turn, explains the absence of effective non-invasive methods for its detection. This review discusses up-to-date aspects of the interaction between the microbiota and immune system factors leading to inflammation and T-cell polarization, and their participation in heart transplant rejection. Special attention is paid to the role of microvesicles in immune response modulation within heart transplant rejection. |
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| ISSN: | 1560-4071 2618-7620 |