Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur
Context: Knee osteoarthritis, a global joint disorder, affects 22%–39% of the population, with a higher incidence in India among women aged 65 and above. Biochemical markers like cytokines could help detect and treat the disease, potentially reducing socioeconomic costs and enabling a transition fro...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1452_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839638110473814016 |
|---|---|
| author | Abhishek Guria Vibhas Chandra Bhaskar Bej Kumar Vimal Rajan K. Barnwal Uma S. Singh Kuber C. Setua |
| author_facet | Abhishek Guria Vibhas Chandra Bhaskar Bej Kumar Vimal Rajan K. Barnwal Uma S. Singh Kuber C. Setua |
| author_sort | Abhishek Guria |
| collection | DOAJ |
| description | Context:
Knee osteoarthritis, a global joint disorder, affects 22%–39% of the population, with a higher incidence in India among women aged 65 and above. Biochemical markers like cytokines could help detect and treat the disease, potentially reducing socioeconomic costs and enabling a transition from degenerative to mechanical stress-induced disease.
Aims:
To investigate the epidemiology of osteoarthritis in knee pain in adults, its clinical and radiological evaluation, and its association with inflammatory markers.
Settings and Design:
The Department of Orthopaedics at MGMMCH, Jamshedpur, conducted this cross-sectional study.
Methods and Material:
The study analyzed 170 patients with knee OA symptoms from August 2023 to February 2024, using the KOOS Knee Survey clinical criteria. We used the Kellgren and Lawrence scale for radiological diagnosis of knee osteoarthritis.
Statistical Analysis Used:
The study utilized descriptive statistics, Chi-square test, and bivariate Spearman’s correlation, with statistical significance determined by P values of <0.05.
Results:
We found that the overall prevalence of knee Osteoarthritis was 70%. We discovered that 59.4% of us were male. The majority were aged 40–49 (32%), 50–59 (25.3%), and 30–39 (14.1%). The grade of knee pain showed a statistically significant strong positive correlation (P = 0.000) between age, Body mass index, C-reactive protein, Rheumatoid factor, Interleukin-6, Interleukin 1β, and TNFα.
Conclusions:
Knee osteoarthritis is prevalent in younger individuals, with males more affected. Elevated IL6, IL1β, and TNFα levels in meniscectomy patients increase osteoarthritis risk, potentially aiding targeted treatment. |
| format | Article |
| id | doaj-art-7b62f2f73dbc45e7b84c7e23d87836c7 |
| institution | Matheson Library |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-7b62f2f73dbc45e7b84c7e23d87836c72025-07-05T11:20:14ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-06-011462242225010.4103/jfmpc.jfmpc_1452_24Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, JamshedpurAbhishek GuriaVibhas ChandraBhaskar BejKumar VimalRajan K. BarnwalUma S. SinghKuber C. SetuaContext: Knee osteoarthritis, a global joint disorder, affects 22%–39% of the population, with a higher incidence in India among women aged 65 and above. Biochemical markers like cytokines could help detect and treat the disease, potentially reducing socioeconomic costs and enabling a transition from degenerative to mechanical stress-induced disease. Aims: To investigate the epidemiology of osteoarthritis in knee pain in adults, its clinical and radiological evaluation, and its association with inflammatory markers. Settings and Design: The Department of Orthopaedics at MGMMCH, Jamshedpur, conducted this cross-sectional study. Methods and Material: The study analyzed 170 patients with knee OA symptoms from August 2023 to February 2024, using the KOOS Knee Survey clinical criteria. We used the Kellgren and Lawrence scale for radiological diagnosis of knee osteoarthritis. Statistical Analysis Used: The study utilized descriptive statistics, Chi-square test, and bivariate Spearman’s correlation, with statistical significance determined by P values of <0.05. Results: We found that the overall prevalence of knee Osteoarthritis was 70%. We discovered that 59.4% of us were male. The majority were aged 40–49 (32%), 50–59 (25.3%), and 30–39 (14.1%). The grade of knee pain showed a statistically significant strong positive correlation (P = 0.000) between age, Body mass index, C-reactive protein, Rheumatoid factor, Interleukin-6, Interleukin 1β, and TNFα. Conclusions: Knee osteoarthritis is prevalent in younger individuals, with males more affected. Elevated IL6, IL1β, and TNFα levels in meniscectomy patients increase osteoarthritis risk, potentially aiding targeted treatment.https://journals.lww.com/10.4103/jfmpc.jfmpc_1452_24interleukin 1βinterleukin-6knee painosteoarthritistumor necrosis factor α |
| spellingShingle | Abhishek Guria Vibhas Chandra Bhaskar Bej Kumar Vimal Rajan K. Barnwal Uma S. Singh Kuber C. Setua Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur Journal of Family Medicine and Primary Care interleukin 1β interleukin-6 knee pain osteoarthritis tumor necrosis factor α |
| title | Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur |
| title_full | Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur |
| title_fullStr | Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur |
| title_full_unstemmed | Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur |
| title_short | Clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at MGM Medical College Hospital, Jamshedpur |
| title_sort | clinical and radiological evaluation of osteoarthritis in knee pain patients and its association with inflammatory markers at mgm medical college hospital jamshedpur |
| topic | interleukin 1β interleukin-6 knee pain osteoarthritis tumor necrosis factor α |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1452_24 |
| work_keys_str_mv | AT abhishekguria clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT vibhaschandra clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT bhaskarbej clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT kumarvimal clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT rajankbarnwal clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT umassingh clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur AT kubercsetua clinicalandradiologicalevaluationofosteoarthritisinkneepainpatientsanditsassociationwithinflammatorymarkersatmgmmedicalcollegehospitaljamshedpur |