Cytoskeletal Proteins and Alzheimer’s Disease Pathogenesis: Focusing on the Interplay with Tau Pathology

Cytoskeletal Proteins and Alzheimer’s Disease Pathogenesis: Focusing on the Interplay with Tau Pathology

The aggregation of Tau protein into neurofibrillary tangles (NFTs), a hallmark of Alzheimer’s disease (AD), is associated with cognitive decline. Recent studies have revealed that neuronal cytoskeletal instability drives early AD pathogenesis. The physiological interaction between tau and the microt...

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Bibliographic Details
Main Authors: Gege Jiang, Guanfeng Xie, Xiaoyi Li, Jing Xiong
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
early stage
neuronal cytoskeleton
tau
post-translationally modified
Online Access:https://www.mdpi.com/2218-273X/15/6/831
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