The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease
Aim: to evaluate the effect of combined therapy with a proton pump inhibitor and rebamipide on clinical manifestations and morphofunctional changes in the esophageal mucosa in patients with non-erosive reflux disease.Materials and methods. The study included 39 patients with non-erosive reflux disea...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2025-06-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1695 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839586397080518656 |
|---|---|
| author | A. A. Makushina A. S. Trukhmanov A. B. Ponomarev O. A. Storonova A. V. Paraskevova P. G. Ermishina V. A. Mironova V. T. Ivashkin |
| author_facet | A. A. Makushina A. S. Trukhmanov A. B. Ponomarev O. A. Storonova A. V. Paraskevova P. G. Ermishina V. A. Mironova V. T. Ivashkin |
| author_sort | A. A. Makushina |
| collection | DOAJ |
| description | Aim: to evaluate the effect of combined therapy with a proton pump inhibitor and rebamipide on clinical manifestations and morphofunctional changes in the esophageal mucosa in patients with non-erosive reflux disease.Materials and methods. The study included 39 patients with non-erosive reflux disease randomized into the main group (omeprazole 20 mg/day + rebamipide 300 mg/day) and the comparison group (omeprazole 20 mg/day). The duration of treatment was 4 weeks. Histological examination of esophageal mucosa biopsies (hematoxylin-eosin staining), morphometry of intercellular spaces, and immunohistochemical assessment of tight junction protein expression (claudin-1, -4, occludin) were performed. Symptoms were evaluated using the Likert scale.Results. The combined therapy group showed significant reductions in heartburn severity (p < 0.001) and belching (p = 0.004), with absent/mild symptoms in 63.7 and 72.4 % of patients, respectively. In the proton pump inhibitor monotherapy group, 53 % of patients retained moderate or severe heartburn. Morphologically, the combined group demonstrated reduced eosinophilic infiltration (p = 0.030). Occludin expression increased in both groups but reached statistical significance only in the monotherapy group (p = 0.046).Conclusion. The combined therapy with proton pump inhibitor and rebamipide improves symptoms and morphological outcomes in non-erosive reflux disease. Increased occludin expression suggests restored integrity of intercellular junctions. Further studies with larger cohorts and extended follow-up are needed to confirm these findings. |
| format | Article |
| id | doaj-art-7a724dd0cef848009f1b4f5d2e09d3a1 |
| institution | Matheson Library |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-7a724dd0cef848009f1b4f5d2e09d3a12025-08-03T19:25:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732025-06-01352698210.22416/1382-4376-2025-1695-46151210The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux DiseaseA. A. Makushina0A. S. Trukhmanov1A. B. Ponomarev2O. A. Storonova3A. V. Paraskevova4P. G. Ermishina5V. A. Mironova6V. T. Ivashkin7I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to evaluate the effect of combined therapy with a proton pump inhibitor and rebamipide on clinical manifestations and morphofunctional changes in the esophageal mucosa in patients with non-erosive reflux disease.Materials and methods. The study included 39 patients with non-erosive reflux disease randomized into the main group (omeprazole 20 mg/day + rebamipide 300 mg/day) and the comparison group (omeprazole 20 mg/day). The duration of treatment was 4 weeks. Histological examination of esophageal mucosa biopsies (hematoxylin-eosin staining), morphometry of intercellular spaces, and immunohistochemical assessment of tight junction protein expression (claudin-1, -4, occludin) were performed. Symptoms were evaluated using the Likert scale.Results. The combined therapy group showed significant reductions in heartburn severity (p < 0.001) and belching (p = 0.004), with absent/mild symptoms in 63.7 and 72.4 % of patients, respectively. In the proton pump inhibitor monotherapy group, 53 % of patients retained moderate or severe heartburn. Morphologically, the combined group demonstrated reduced eosinophilic infiltration (p = 0.030). Occludin expression increased in both groups but reached statistical significance only in the monotherapy group (p = 0.046).Conclusion. The combined therapy with proton pump inhibitor and rebamipide improves symptoms and morphological outcomes in non-erosive reflux disease. Increased occludin expression suggests restored integrity of intercellular junctions. Further studies with larger cohorts and extended follow-up are needed to confirm these findings.https://www.gastro-j.ru/jour/article/view/1695proton pump inhibitorsnon-erosive reflux diseaseepithelial protective therapytight junction proteins |
| spellingShingle | A. A. Makushina A. S. Trukhmanov A. B. Ponomarev O. A. Storonova A. V. Paraskevova P. G. Ermishina V. A. Mironova V. T. Ivashkin The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии proton pump inhibitors non-erosive reflux disease epithelial protective therapy tight junction proteins |
| title | The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease |
| title_full | The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease |
| title_fullStr | The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease |
| title_full_unstemmed | The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease |
| title_short | The Effect of Combined Therapy with a Proton Pump Inhibitor and Rebamipide on the Clinical Course and Morphofunctional Changes of the Esophageal Mucosa in Patients with Non-Erosive Reflux Disease |
| title_sort | effect of combined therapy with a proton pump inhibitor and rebamipide on the clinical course and morphofunctional changes of the esophageal mucosa in patients with non erosive reflux disease |
| topic | proton pump inhibitors non-erosive reflux disease epithelial protective therapy tight junction proteins |
| url | https://www.gastro-j.ru/jour/article/view/1695 |
| work_keys_str_mv | AT aamakushina theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT astrukhmanov theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT abponomarev theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT oastoronova theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT avparaskevova theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT pgermishina theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT vamironova theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT vtivashkin theeffectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT aamakushina effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT astrukhmanov effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT abponomarev effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT oastoronova effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT avparaskevova effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT pgermishina effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT vamironova effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease AT vtivashkin effectofcombinedtherapywithaprotonpumpinhibitorandrebamipideontheclinicalcourseandmorphofunctionalchangesoftheesophagealmucosainpatientswithnonerosiverefluxdisease |