Clinical and Epidemiological Aspects on Healthcare-Associated Infections with <i>Acinetobacter</i> spp. in a Neurosurgery Hospital in North-East Romania
<i>Background and Objectives</i>: Healthcare-associated infections (HAIs) are on the rise worldwide because the range of etiologic agents involved is very diverse and their antimicrobial resistance poses a threat to population health in the third millennium. <i>Materials and Method...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/6/990 |
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| Summary: | <i>Background and Objectives</i>: Healthcare-associated infections (HAIs) are on the rise worldwide because the range of etiologic agents involved is very diverse and their antimicrobial resistance poses a threat to population health in the third millennium. <i>Materials and Methods</i>: We conducted a retrospective, longitudinal, descriptive clinical–epidemiological study in a hospital with a neurosurgical profile in northeastern Romania (“Prof. Dr. N. Oblu” Clinical Emergency Hospital in Iasi), during 2020–2024. The study is centered on the involvement of <i>Acinetobacter</i> spp. in the occurrence and evolution of HAIs. <i>Results</i>: The highest incidence of <i>Acinetobacter</i> spp. HAIs was recorded in the intensive care unit (ICU)—82.78% compared to neurosurgical wards (15.38%), with predominance in males (69.23%) and rural residence patients (55.67%). Most HAIs were represented by ventilator-associated pneumonia (42.13%) and lower respiratory tract infections (23.08%). Strains with high virulence and pathogenicity (CR-MDR, ESBL-MDR) were found, with the highest proportion of CR-MDR strains (88.27%). <i>Conclusions</i>: Our study provides useful data for surveillance of the antimicrobial resistance of pathogens involved in HAIs at the hospital level and for guiding antibiotic therapy in hospital-acquired infections. |
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| ISSN: | 1010-660X 1648-9144 |