Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry
Sensory gating (SG) is a protective mechanism that prevents sensory overload by attenuating neural responses to repeated stimuli while allowing allocation of neural resources to salient inputs. While studies using conventional, cryogenic magnetoencephalography (MEG) have provided a foundational unde...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925003969 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839612768083247104 |
|---|---|
| author | Yasra Arif Elizabeth Heinrichs-Graham Alexa M. Wildy Thomas W. Ward Augusto Diedrich Christine M. Embury Maggie P. Rempe Ryan J. Glesinger Zhiying Shen Kellen M. McDonald Peihan J. Huang Seth Bashford Brittany K. Taylor Max J. Kurz Tony W. Wilson |
| author_facet | Yasra Arif Elizabeth Heinrichs-Graham Alexa M. Wildy Thomas W. Ward Augusto Diedrich Christine M. Embury Maggie P. Rempe Ryan J. Glesinger Zhiying Shen Kellen M. McDonald Peihan J. Huang Seth Bashford Brittany K. Taylor Max J. Kurz Tony W. Wilson |
| author_sort | Yasra Arif |
| collection | DOAJ |
| description | Sensory gating (SG) is a protective mechanism that prevents sensory overload by attenuating neural responses to repeated stimuli while allowing allocation of neural resources to salient inputs. While studies using conventional, cryogenic magnetoencephalography (MEG) have provided a foundational understanding of the neurophysiological spectro-temporal profile of sensory gating in somatosensory cortices, its utility in diverse populations is constrained by technical limitations, including movement restriction and a one-size-fits-all helmet design. Recent developments in optically pumped magnetometry (OPM) aim to overcome these constraints by providing greater tolerance to movement and customizable helmet sizes. A small number of studies have documented the reliability of OPM in mapping somatosensory responses to median nerve stimulation using OPM; however, none have examined SG. In this study, we utilized a whole-head 128-channel OPM system and a paired-pulse median nerve stimulation paradigm to examine somato-SG and map the precise spectro-temporal cortical dynamics in a group of 31 healthy adults. Neural responses per stimulation were imaged in both the time-frequency and time domains, and voxel time series data were extracted to quantify the dynamics of somato-SG. Robust gating effects were observed in the peak and average neural responses within the primary somatosensory cortices, in both the oscillatory and time domains. These findings underscore OPM’s ability to precisely resolve the spatiotemporal neural dynamics of somato-SG and stress the utility of OPM in examining somatosensory processes across developmental trajectories extending down to infants, as well as in clinical populations. |
| format | Article |
| id | doaj-art-7a38a8f95a3d4cb396bce85d3a689ee7 |
| institution | Matheson Library |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-7a38a8f95a3d4cb396bce85d3a689ee72025-07-28T04:16:10ZengElsevierNeuroImage1095-95722025-09-01318121393Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometryYasra Arif0Elizabeth Heinrichs-Graham1Alexa M. Wildy2Thomas W. Ward3Augusto Diedrich4Christine M. Embury5Maggie P. Rempe6Ryan J. Glesinger7Zhiying Shen8Kellen M. McDonald9Peihan J. Huang10Seth Bashford11Brittany K. Taylor12Max J. Kurz13Tony W. Wilson14Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Corresponding author at: Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE, 68198, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, 68178, USASensory gating (SG) is a protective mechanism that prevents sensory overload by attenuating neural responses to repeated stimuli while allowing allocation of neural resources to salient inputs. While studies using conventional, cryogenic magnetoencephalography (MEG) have provided a foundational understanding of the neurophysiological spectro-temporal profile of sensory gating in somatosensory cortices, its utility in diverse populations is constrained by technical limitations, including movement restriction and a one-size-fits-all helmet design. Recent developments in optically pumped magnetometry (OPM) aim to overcome these constraints by providing greater tolerance to movement and customizable helmet sizes. A small number of studies have documented the reliability of OPM in mapping somatosensory responses to median nerve stimulation using OPM; however, none have examined SG. In this study, we utilized a whole-head 128-channel OPM system and a paired-pulse median nerve stimulation paradigm to examine somato-SG and map the precise spectro-temporal cortical dynamics in a group of 31 healthy adults. Neural responses per stimulation were imaged in both the time-frequency and time domains, and voxel time series data were extracted to quantify the dynamics of somato-SG. Robust gating effects were observed in the peak and average neural responses within the primary somatosensory cortices, in both the oscillatory and time domains. These findings underscore OPM’s ability to precisely resolve the spatiotemporal neural dynamics of somato-SG and stress the utility of OPM in examining somatosensory processes across developmental trajectories extending down to infants, as well as in clinical populations.http://www.sciencedirect.com/science/article/pii/S1053811925003969GammaThetaVirtual sensorBeamformersLORETA |
| spellingShingle | Yasra Arif Elizabeth Heinrichs-Graham Alexa M. Wildy Thomas W. Ward Augusto Diedrich Christine M. Embury Maggie P. Rempe Ryan J. Glesinger Zhiying Shen Kellen M. McDonald Peihan J. Huang Seth Bashford Brittany K. Taylor Max J. Kurz Tony W. Wilson Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry NeuroImage Gamma Theta Virtual sensor Beamformer sLORETA |
| title | Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry |
| title_full | Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry |
| title_fullStr | Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry |
| title_full_unstemmed | Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry |
| title_short | Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry |
| title_sort | oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices evidence from optically pumped magnetometry |
| topic | Gamma Theta Virtual sensor Beamformer sLORETA |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925003969 |
| work_keys_str_mv | AT yasraarif oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT elizabethheinrichsgraham oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT alexamwildy oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT thomaswward oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT augustodiedrich oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT christinemembury oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT maggieprempe oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT ryanjglesinger oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT zhiyingshen oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT kellenmmcdonald oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT peihanjhuang oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT sethbashford oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT brittanyktaylor oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT maxjkurz oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry AT tonywwilson oscillatoryandevokedneuralresponsesunderlyinggatingintheprimarysomatosensorycorticesevidencefromopticallypumpedmagnetometry |