Enhancing targeted delivery and efficacy of PEGylated liposomal doxorubicin with liposomal minoxidil: comprehensive in silico, in vitro, and in vivo tumor model studies

Enhancing targeted delivery and efficacy of PEGylated liposomal doxorubicin with liposomal minoxidil: comprehensive in silico, in vitro, and in vivo tumor model studies

The therapeutic efficacy of nanoparticle (NP)-encapsulated cytotoxic drugs has remained limited by poor penetration into solid tumors. To address this challenge, we developed a novel strategy using minoxidil-loaded nanoliposomes (Lip-MXD) to induce tumor vasodilation and enhance the delivery of PEGy...

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Bibliographic Details
Main Authors: Vahideh Mohammadzadeh, Leila Arabi, Seyedeh Maryam Hosseinikhah, Mohammad Mashreghi, Fatemeh Kalalinia, Neda Mostajeran, Mohammad Reza Zirak, Farzin Hadizadeh, Mojgan Nejabat, Hossein Kamali, Niloufar Rahiman, Mahmoud Reza Jaafari
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
Tumor microenvironment
Tight junction proteins
Minoxidil
PEGylated liposomal doxorubicin
Desmoplastic tumors
Claudin-1
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2536802
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https://www.tandfonline.com/doi/10.1080/10717544.2025.2536802

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