Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study
IntroductionThe gut microbiota plays a crucial role in the development of atherosclerosis. The Dietary Index for Gut Microbiota (DI-GM) assesses the impact of diet on gut microbiota, and the Atherogenic Index of Plasma (AIP) serves as a key marker for evaluating atherosclerosis. However, studies exp...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1556650/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839639779402055680 |
|---|---|
| author | Tian-Ding Liu Yang-Yang Zheng Jin-Ying Zhang |
| author_facet | Tian-Ding Liu Yang-Yang Zheng Jin-Ying Zhang |
| author_sort | Tian-Ding Liu |
| collection | DOAJ |
| description | IntroductionThe gut microbiota plays a crucial role in the development of atherosclerosis. The Dietary Index for Gut Microbiota (DI-GM) assesses the impact of diet on gut microbiota, and the Atherogenic Index of Plasma (AIP) serves as a key marker for evaluating atherosclerosis. However, studies exploring the association between DI-GM and AIP remain limited.MethodsData from the 2007–2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 15,471 participants. Weighted multivariate linear regression models were employed to evaluate the linear association between DI-GM and AIP, while restricted cubic splines (RCS) were used to assess potential nonlinear relationships.ResultsAfter adjusting for confounding factors, multivariate linear regression analysis demonstrated a significant negative correlation between DI-GM levels and AIP. Each one-point increase in DI-GM was associated with a 0.007-point reduction in AIP (95% CI: −0.012 to −0.002). Categorical analysis further revealed that participants in the DI-GM ≥6 group had significantly lower AIP levels compared to those in lower DI-GM groups (β = −0.038, 95% CI: −0.059 to −0.017; P for trend = 0.007). Restricted cubic spline (RCS) analysis identified a significant non-linear dose-response relationship (P for non-linearity = 0.018) with a threshold at DI-GM = 3.467. Below this threshold, the association was nonsignificant; however, above it, each unit increase in DI-GM corresponded to a 0.011 decrease in AIP (P < 0.001). Subgroup analyses indicated that the relationship between DI-GM and AIP was significantly moderated by age, race/ethnicity, hypertension, and diabetes (P for interaction < 0.05).ConclusionThis study demonstrated a non-linear dose-response relationship between DI-GM levels and AIP, with a significant threshold effect at DI-GM = 3.467. Beyond this threshold, higher DI-GM levels were linked to lower AIP, moderated by age, race/ethnicity, hypertension, and diabetes. |
| format | Article |
| id | doaj-art-78b7ee438f9d42de85cbf32d43e204f8 |
| institution | Matheson Library |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-78b7ee438f9d42de85cbf32d43e204f82025-07-04T05:16:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-07-011210.3389/fcvm.2025.15566501556650Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional studyTian-Ding Liu0Yang-Yang Zheng1Jin-Ying Zhang2Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of General Surgery, National Center of Gerontology, Beijing Hospital, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaIntroductionThe gut microbiota plays a crucial role in the development of atherosclerosis. The Dietary Index for Gut Microbiota (DI-GM) assesses the impact of diet on gut microbiota, and the Atherogenic Index of Plasma (AIP) serves as a key marker for evaluating atherosclerosis. However, studies exploring the association between DI-GM and AIP remain limited.MethodsData from the 2007–2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 15,471 participants. Weighted multivariate linear regression models were employed to evaluate the linear association between DI-GM and AIP, while restricted cubic splines (RCS) were used to assess potential nonlinear relationships.ResultsAfter adjusting for confounding factors, multivariate linear regression analysis demonstrated a significant negative correlation between DI-GM levels and AIP. Each one-point increase in DI-GM was associated with a 0.007-point reduction in AIP (95% CI: −0.012 to −0.002). Categorical analysis further revealed that participants in the DI-GM ≥6 group had significantly lower AIP levels compared to those in lower DI-GM groups (β = −0.038, 95% CI: −0.059 to −0.017; P for trend = 0.007). Restricted cubic spline (RCS) analysis identified a significant non-linear dose-response relationship (P for non-linearity = 0.018) with a threshold at DI-GM = 3.467. Below this threshold, the association was nonsignificant; however, above it, each unit increase in DI-GM corresponded to a 0.011 decrease in AIP (P < 0.001). Subgroup analyses indicated that the relationship between DI-GM and AIP was significantly moderated by age, race/ethnicity, hypertension, and diabetes (P for interaction < 0.05).ConclusionThis study demonstrated a non-linear dose-response relationship between DI-GM levels and AIP, with a significant threshold effect at DI-GM = 3.467. Beyond this threshold, higher DI-GM levels were linked to lower AIP, moderated by age, race/ethnicity, hypertension, and diabetes.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1556650/fullgut microbiotadietary index for gut microbiotacardiovascular diseaseatherogenic index of plasmanational health and nutrition examination survey |
| spellingShingle | Tian-Ding Liu Yang-Yang Zheng Jin-Ying Zhang Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study Frontiers in Cardiovascular Medicine gut microbiota dietary index for gut microbiota cardiovascular disease atherogenic index of plasma national health and nutrition examination survey |
| title | Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study |
| title_full | Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study |
| title_fullStr | Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study |
| title_full_unstemmed | Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study |
| title_short | Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study |
| title_sort | non linear association between the dietary index for gut microbiota and the atherogenic index of plasma insights from a cross sectional study |
| topic | gut microbiota dietary index for gut microbiota cardiovascular disease atherogenic index of plasma national health and nutrition examination survey |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1556650/full |
| work_keys_str_mv | AT tiandingliu nonlinearassociationbetweenthedietaryindexforgutmicrobiotaandtheatherogenicindexofplasmainsightsfromacrosssectionalstudy AT yangyangzheng nonlinearassociationbetweenthedietaryindexforgutmicrobiotaandtheatherogenicindexofplasmainsightsfromacrosssectionalstudy AT jinyingzhang nonlinearassociationbetweenthedietaryindexforgutmicrobiotaandtheatherogenicindexofplasmainsightsfromacrosssectionalstudy |