The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.
<h4>Background</h4>Accumulating evidence supports a role of DNA methylation in the pathogenesis of leukemia. The aim of our study was to evaluate the potential genes with aberrant DNA methylation in the prediction of leukemia risk by a comprehensive meta-analysis of the published data.&l...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0096822 |
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| author | Danjie Jiang Qingxiao Hong Yusheng Shen Yan Xu Huangkai Zhu Yirun Li Chunjing Xu Guifang Ouyang Shiwei Duan |
| author_facet | Danjie Jiang Qingxiao Hong Yusheng Shen Yan Xu Huangkai Zhu Yirun Li Chunjing Xu Guifang Ouyang Shiwei Duan |
| author_sort | Danjie Jiang |
| collection | DOAJ |
| description | <h4>Background</h4>Accumulating evidence supports a role of DNA methylation in the pathogenesis of leukemia. The aim of our study was to evaluate the potential genes with aberrant DNA methylation in the prediction of leukemia risk by a comprehensive meta-analysis of the published data.<h4>Methods</h4>A series of meta-analyses were done among the eligible studies that were harvested after a careful filtration of the searching results from PubMed literature database. Mantel-Haenszel odds ratios and 95% confidence intervals were computed for each methylation event assuming the appropriate model.<h4>Results</h4>A total of 535 publications were initially retrieved from PubMed literature database. After a three-step filtration, we harvested 41 case-control articles that studied the role of gene methylation in the prediction of leukemia risk. Among the involving 30 genes, 20 genes were shown to be aberrantly methylated in the leukemia patients. A further subgroup meta-analysis by subtype of leukemia showed that CDKN2A, CDKN2B, ID4 genes were significantly hypermethylated in acute myeloid leukemia.<h4>Conclusions</h4>Our meta-analyses identified strong associations between a number of genes with aberrant DNA methylation and leukemia. Further studies should be required to confirm the results in the future. |
| format | Article |
| id | doaj-art-77e83fea9b8e45efa8ce598d2ef1f18f |
| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-77e83fea9b8e45efa8ce598d2ef1f18f2025-07-30T05:31:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9682210.1371/journal.pone.0096822The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.Danjie JiangQingxiao HongYusheng ShenYan XuHuangkai ZhuYirun LiChunjing XuGuifang OuyangShiwei Duan<h4>Background</h4>Accumulating evidence supports a role of DNA methylation in the pathogenesis of leukemia. The aim of our study was to evaluate the potential genes with aberrant DNA methylation in the prediction of leukemia risk by a comprehensive meta-analysis of the published data.<h4>Methods</h4>A series of meta-analyses were done among the eligible studies that were harvested after a careful filtration of the searching results from PubMed literature database. Mantel-Haenszel odds ratios and 95% confidence intervals were computed for each methylation event assuming the appropriate model.<h4>Results</h4>A total of 535 publications were initially retrieved from PubMed literature database. After a three-step filtration, we harvested 41 case-control articles that studied the role of gene methylation in the prediction of leukemia risk. Among the involving 30 genes, 20 genes were shown to be aberrantly methylated in the leukemia patients. A further subgroup meta-analysis by subtype of leukemia showed that CDKN2A, CDKN2B, ID4 genes were significantly hypermethylated in acute myeloid leukemia.<h4>Conclusions</h4>Our meta-analyses identified strong associations between a number of genes with aberrant DNA methylation and leukemia. Further studies should be required to confirm the results in the future.https://doi.org/10.1371/journal.pone.0096822 |
| spellingShingle | Danjie Jiang Qingxiao Hong Yusheng Shen Yan Xu Huangkai Zhu Yirun Li Chunjing Xu Guifang Ouyang Shiwei Duan The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. PLoS ONE |
| title | The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. |
| title_full | The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. |
| title_fullStr | The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. |
| title_full_unstemmed | The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. |
| title_short | The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis. |
| title_sort | diagnostic value of dna methylation in leukemia a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0096822 |
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