Application of Solvent Evaporation to Generate Supersaturated Lipid-Based Formulations: Investigation of Drug Load and Formulation Quality

Application of Solvent Evaporation to Generate Supersaturated Lipid-Based Formulations: Investigation of Drug Load and Formulation Quality

<b>Background/Objectives:</b> Lipid-based formulations (LBFs) are enabling formulations for poorly water-soluble, mostly lipophilic drugs. In LBFs, the drug is pre-dissolved in the formulation which can consist of lipids, surfactants, and/or cosolvents. In cases where the administration...

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Bibliographic Details
Main Authors: Felix Paulus, Jef Stappaerts, Annette Bauer-Brandl, Dirk Lauwers, Liesbet Smet, Eline Hermans, René Holm
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
supersaturated lipid-based formulations
lipid-based drug delivery systems
solubility
supersaturation
residual solvents
Online Access:https://www.mdpi.com/1999-4923/17/6/702
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