Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis
Objectives: Pancreatic stone protein (PSP) has been identified as an indicator of systemic stress and is elevated in individuals diagnosed with type 2 diabetes mellitus (T2DM), potentially serving as a prognostic marker for both the onset and progression of the disease. Materials and Methods: This s...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Tzu Chi Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/tcmj.tcmj_211_24 |
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| _version_ | 1839637808578297856 |
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| author | Nicolas Daniel Widjanarko Nanny Natalia Mulyani Soetedjo Maria Riastuti Iryaningrum Erlangga Saputra Arifin Steven Alvianto Stevan Kristian Lionardi Archie Fontana Iskandar Kevin Axel Chandra |
| author_facet | Nicolas Daniel Widjanarko Nanny Natalia Mulyani Soetedjo Maria Riastuti Iryaningrum Erlangga Saputra Arifin Steven Alvianto Stevan Kristian Lionardi Archie Fontana Iskandar Kevin Axel Chandra |
| author_sort | Nicolas Daniel Widjanarko |
| collection | DOAJ |
| description | Objectives:
Pancreatic stone protein (PSP) has been identified as an indicator of systemic stress and is elevated in individuals diagnosed with type 2 diabetes mellitus (T2DM), potentially serving as a prognostic marker for both the onset and progression of the disease.
Materials and Methods:
This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 guidelines. Articles were sourced from MEDLINE, ProQuest, Science Direct, Google Scholar, and Cochrane Library electronic databases. Studies included are all observational studies examining PSP/Reg1α serum levels in patients with T2DM. The quality of the study was evaluated using the Newcastle–Ottawa Scale, as well as Review Manager 5.4 to perform the meta-analysis.
Results:
Seven studies met the criteria for inclusion. Pooled analysis revealed significant differences in PSP values between T2DM individuals and healthy controls (standardized mean difference [SMD] = 2.14, 95% confidence interval CI: 1.05–1.92, P < 0.00001). Further subgroup analysis showed PSP was substantially higher in T2DM with complications (SMD = −1.57, 95% CI: −2.12 to −1.02, P < 0.00001) compared to T2DM without complications (SMD = −1.39, 95% CI: −2.17 to − 0.61) and newly diagnosed T2DM (SMD = −1.85, 95% CI: −2.96 to −0.74). Grading of Recommendations, Assessment, Development, and Evaluations demonstrated moderate quality of evidence.
Conclusion:
Our analysis revealed a progressive elevation in PSP values concomitant with the worsening T2DM disease state across the entire spectrum. PSP exhibits promising potential as a biomarker for predicting both disease initiation and subsequent clinical course. |
| format | Article |
| id | doaj-art-76ea8c6f2da64f3e96e450b9f35b1911 |
| institution | Matheson Library |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-76ea8c6f2da64f3e96e450b9f35b19112025-07-06T09:45:49ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562025-07-0137332833810.4103/tcmj.tcmj_211_24Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysisNicolas Daniel WidjanarkoNanny Natalia Mulyani SoetedjoMaria Riastuti IryaningrumErlangga Saputra ArifinSteven AlviantoStevan Kristian LionardiArchie Fontana IskandarKevin Axel ChandraObjectives: Pancreatic stone protein (PSP) has been identified as an indicator of systemic stress and is elevated in individuals diagnosed with type 2 diabetes mellitus (T2DM), potentially serving as a prognostic marker for both the onset and progression of the disease. Materials and Methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 guidelines. Articles were sourced from MEDLINE, ProQuest, Science Direct, Google Scholar, and Cochrane Library electronic databases. Studies included are all observational studies examining PSP/Reg1α serum levels in patients with T2DM. The quality of the study was evaluated using the Newcastle–Ottawa Scale, as well as Review Manager 5.4 to perform the meta-analysis. Results: Seven studies met the criteria for inclusion. Pooled analysis revealed significant differences in PSP values between T2DM individuals and healthy controls (standardized mean difference [SMD] = 2.14, 95% confidence interval CI: 1.05–1.92, P < 0.00001). Further subgroup analysis showed PSP was substantially higher in T2DM with complications (SMD = −1.57, 95% CI: −2.12 to −1.02, P < 0.00001) compared to T2DM without complications (SMD = −1.39, 95% CI: −2.17 to − 0.61) and newly diagnosed T2DM (SMD = −1.85, 95% CI: −2.96 to −0.74). Grading of Recommendations, Assessment, Development, and Evaluations demonstrated moderate quality of evidence. Conclusion: Our analysis revealed a progressive elevation in PSP values concomitant with the worsening T2DM disease state across the entire spectrum. PSP exhibits promising potential as a biomarker for predicting both disease initiation and subsequent clinical course.https://journals.lww.com/10.4103/tcmj.tcmj_211_24pancreatic stone proteinregenerating proteintype 2 diabetes mellitus |
| spellingShingle | Nicolas Daniel Widjanarko Nanny Natalia Mulyani Soetedjo Maria Riastuti Iryaningrum Erlangga Saputra Arifin Steven Alvianto Stevan Kristian Lionardi Archie Fontana Iskandar Kevin Axel Chandra Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis Tzu Chi Medical Journal pancreatic stone protein regenerating protein type 2 diabetes mellitus |
| title | Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis |
| title_full | Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis |
| title_fullStr | Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis |
| title_full_unstemmed | Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis |
| title_short | Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis |
| title_sort | pancreatic stone protein as a novel biomarker of microvascular complications in type ii diabetes mellitus a systematic review and meta analysis |
| topic | pancreatic stone protein regenerating protein type 2 diabetes mellitus |
| url | https://journals.lww.com/10.4103/tcmj.tcmj_211_24 |
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