Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies

Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies

Multiple myeloma (MM) is a hematological tumor characterized by the malignant proliferation of plasma cells in bone marrow (BM). Despite the prolonged survival of MM patients, a significant amount of patients relapse or become drug resistant. This underlines the importance of the development and inv...

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Bibliographic Details
Main Authors: Xiaoran Chen, Jiale Zhou, Xiaoqing Dong, Yan Xu, Bing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
E3 ubiquitin ligases
multiple myeloma
pathogenesis
therapeutic targets
immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1620097/full
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