AGEs-RAGE manipulates tumor intrinsic pERK/Sp1/IL6 pathway and reprograms macrophage to promote intrahepatic cholangiocarcinoma progression

AGEs-RAGE manipulates tumor intrinsic pERK/Sp1/IL6 pathway and reprograms macrophage to promote intrahepatic cholangiocarcinoma progression

Tumors often exhibit oxygen deprivation and enhanced glucose uptake, leading to glycolysis. Advanced glycation end products (AGEs) protein modifications induced by hyperglycemia—activate signaling pathways that promote cancer progression upon binding to its receptor (RAGE). In this study, AGEs-treat...

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Bibliographic Details
Main Authors: Juan Zhang, Biyang Jing, Xiaojian Ni, Youpei Lin, Jiaomeng Pan, MaoPei Chen, Boheng Zhang, Lan Zhang, Ningling Ge, Ruyuan Deng, Xiao Wang, Guohe Song
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Translational Oncology
Subjects:
Advanced glycation end products
Receptor for advanced glycation end products
Extracellular signal-regulated kinase
Specificity protein 1
IL-6
Intrahepatic cholangiocarcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001779
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