Consensus Sequences for <i>Gag</i> and <i>Pol</i> Introduced into HIV-1 Clade B Laboratory Strains Differentially Influence the Impact of Point Mutations Associated with Immune Escape and with Drug Resistance on Viral Replicative Capacity

Consensus Sequences for <i>Gag</i> and <i>Pol</i> Introduced into HIV-1 Clade B Laboratory Strains Differentially Influence the Impact of Point Mutations Associated with Immune Escape and with Drug Resistance on Viral Replicative Capacity

Viral evasion from effective human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses and from antiretroviral therapy through viral sequence variation is frequently accompanied by a loss in viral fitness. The impact of sequence variations on replication capacity in vitro was mostly...

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Bibliographic Details
Main Authors: Sven Breitschwerdt, Benedikt Grandel, Benedikt Asbach, Franziska Winter, Todd Allen, Ralf Wagner, Bernd Salzberger, Arne Schneidewind
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
HIV
viral backbone
consensus sequence
immune escape
replication capacity
drug resistance
Online Access:https://www.mdpi.com/1999-4915/17/6/842
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