Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting
Rahmo Mohamed Ali,1 Abdullahi Abdirahman Omar,1 Ismail A Ali2 1Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia; 2Department of Surgery, Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, SomaliaCorrespondenc...
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Dove Medical Press
2025-07-01
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| author | Ali RM Omar AA Ali IA |
| author_facet | Ali RM Omar AA Ali IA |
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| description | Rahmo Mohamed Ali,1 Abdullahi Abdirahman Omar,1 Ismail A Ali2 1Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia; 2Department of Surgery, Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, SomaliaCorrespondence: Rahmo Mohamed Ali, Email rahmomohameda@simad.edu.soIntroduction: Renal cell carcinoma (RCC) is among the most prevalent kidney malignancies and is characterized by a variety of histological subtypes, with clear cell RCC being the most common subtype. Hypertension may occur as a paraneoplastic manifestation, although the resolution of refractory hypertension following radical nephrectomy remains an uncommon event. To our knowledge, this is the first documented case from a resource-limited setting in which refractory hypertension resolved completely following radical nephrectomy for RCC, underscoring unique diagnostic and therapeutic challenges in such environments.Case Presentation: A 56-year-old male presented with severe uncontrolled hypertension accompanied by persistent headaches and palpitations and was unresponsive to standard anti-hypertensive therapy. Clinical examination revealed a palpable mass in the right flank. Abdominal computed tomography revealed a large, heterogeneous mass (approximately 10 cm) occupying the hepatorenal space, which was initially suggestive of pheochromocytoma. Due to limited diagnostic resources, confirmatory biochemical testing was unavailable. The patient underwent radical nephrectomy and histopathology confirmed clear cell RCC (WHO/ISUP grade 2). The patient’s hypertension resolved completely postoperatively, with subsequent follow-ups demonstrating stable blood pressure and no metastatic disease.Conclusion: This case emphasizes an uncommon presentation of refractory hypertension linked directly to RCC that resolved after radical nephrectomy. This case underscores the importance of considering RCC as a differential diagnosis for refractory hypertension, particularly in resource-limited settings where advanced diagnostics and recent surgical are unavailable.Keywords: renal cell carcinoma, refractory hypertension, radical nephrectomy, paraneoplastic syndrome, case report, Somalia |
| format | Article |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
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| series | Cancer Management and Research |
| spelling | doaj-art-74f46304835a4f33bcfee856875c4ee52025-07-13T18:21:55ZengDove Medical PressCancer Management and Research1179-13222025-07-01Volume 17Issue 113691375104771Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit SettingAli RM0Omar AA1Ali IA2SurgerySurgerySurgeryRahmo Mohamed Ali,1 Abdullahi Abdirahman Omar,1 Ismail A Ali2 1Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia; 2Department of Surgery, Dr. Sumait Hospitals, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, SomaliaCorrespondence: Rahmo Mohamed Ali, Email rahmomohameda@simad.edu.soIntroduction: Renal cell carcinoma (RCC) is among the most prevalent kidney malignancies and is characterized by a variety of histological subtypes, with clear cell RCC being the most common subtype. Hypertension may occur as a paraneoplastic manifestation, although the resolution of refractory hypertension following radical nephrectomy remains an uncommon event. To our knowledge, this is the first documented case from a resource-limited setting in which refractory hypertension resolved completely following radical nephrectomy for RCC, underscoring unique diagnostic and therapeutic challenges in such environments.Case Presentation: A 56-year-old male presented with severe uncontrolled hypertension accompanied by persistent headaches and palpitations and was unresponsive to standard anti-hypertensive therapy. Clinical examination revealed a palpable mass in the right flank. Abdominal computed tomography revealed a large, heterogeneous mass (approximately 10 cm) occupying the hepatorenal space, which was initially suggestive of pheochromocytoma. Due to limited diagnostic resources, confirmatory biochemical testing was unavailable. The patient underwent radical nephrectomy and histopathology confirmed clear cell RCC (WHO/ISUP grade 2). The patient’s hypertension resolved completely postoperatively, with subsequent follow-ups demonstrating stable blood pressure and no metastatic disease.Conclusion: This case emphasizes an uncommon presentation of refractory hypertension linked directly to RCC that resolved after radical nephrectomy. This case underscores the importance of considering RCC as a differential diagnosis for refractory hypertension, particularly in resource-limited settings where advanced diagnostics and recent surgical are unavailable.Keywords: renal cell carcinoma, refractory hypertension, radical nephrectomy, paraneoplastic syndrome, case report, Somaliahttps://www.dovepress.com/resolution-of-refractory-hypertension-following-radical-nephrectomy-fo-peer-reviewed-fulltext-article-CMARRenal cell carcinomarefractory hypertensionradical nephrectomyparaneoplastic syndromecase reportSomalia |
| spellingShingle | Ali RM Omar AA Ali IA Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting Cancer Management and Research Renal cell carcinoma refractory hypertension radical nephrectomy paraneoplastic syndrome case report Somalia |
| title | Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting |
| title_full | Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting |
| title_fullStr | Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting |
| title_full_unstemmed | Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting |
| title_short | Resolution of Refractory Hypertension Following Radical Nephrectomy for Renal Cell Carcinoma: A Case Report from Somalia in Resource Limit Setting |
| title_sort | resolution of refractory hypertension following radical nephrectomy for renal cell carcinoma a case report from somalia in resource limit setting |
| topic | Renal cell carcinoma refractory hypertension radical nephrectomy paraneoplastic syndrome case report Somalia |
| url | https://www.dovepress.com/resolution-of-refractory-hypertension-following-radical-nephrectomy-fo-peer-reviewed-fulltext-article-CMAR |
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