Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents
Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2025-07-01
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| Series: | Nanomedicine Journal |
| Subjects: | |
| Online Access: | https://nmj.mums.ac.ir/article_26009_190afb5077ec84064733d3f32579ff7a.pdf |
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| Summary: | Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination of chitosan, PVA, MgCl₂, and GPTMS as a crosslinking agent. Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis characterized the prepared composite scaffold. The composite scaffolds' mechanical properties, bioactivity, biocompatibility, swelling, and degradation were also investigated.Results: Significant improvements in the mechanical properties were observed in the modified composite compared to those seen in the scaffold without MgCl₂. With an increase in MgCl₂ content, the scaffold's degradation and porosity increased, while its swelling capacity decreased. Bioactivity was also enhanced in the composite following the further addition of MgCl₂.Conclusion: In vitro tests for cytotoxicity and MG-63 cell proliferation showed that the composite scaffolds were non-cytotoxic, resulting in better cell adherence and growth on the surface of these scaffolds. |
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| ISSN: | 2322-3049 2322-5904 |