Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction
Aim. To study the levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with acute myocardial infarction (MI).Material and methods. The study included 74 patients with acute MI. PCSK9 was determined by enzyme-linked immunosorbent assay.Results. The mean PCSK9 levels were 479,7±...
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| Language: | Russian |
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«FIRMA «SILICEA» LLC
2020-03-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3724 |
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| author | A. D. Gimadeeva A. S. Galyavich Z. M. Galeeva L. V. Baleeva |
| author_facet | A. D. Gimadeeva A. S. Galyavich Z. M. Galeeva L. V. Baleeva |
| author_sort | A. D. Gimadeeva |
| collection | DOAJ |
| description | Aim. To study the levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with acute myocardial infarction (MI).Material and methods. The study included 74 patients with acute MI. PCSK9 was determined by enzyme-linked immunosorbent assay.Results. The mean PCSK9 levels were 479,7±15,4 ng/ml. No significant correlation was found between PCSK9 and total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides. In the group of smokers, a significant inverse correlation was found between the levels of PCSK9 and HDL-C (-0,45; p=0,039). In the group of patients with body mass index <25 kg/m2, a significant inverse correlation of PCSK9 levels with total cholesterol (-0,45, p=0,008), HDL-C (-0,42; p=0,029) and LDL-C (-0,47; p=0,003) was found.Conclusion. In patients with MI, a correlation of PCSK9 levels with lipid profile was found in smokers, as well as in patients with a low body mass index. |
| format | Article |
| id | doaj-art-732d6e4d8c3e43fdbd0a4f19262b46e5 |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-732d6e4d8c3e43fdbd0a4f19262b46e52025-08-04T13:00:21Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-03-0125210.15829/1560-4071-2020-2-37242845Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarctionA. D. Gimadeeva0A. S. Galyavich1Z. M. Galeeva2L. V. Baleeva3Kazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityKazan State Medical UniversityAim. To study the levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with acute myocardial infarction (MI).Material and methods. The study included 74 patients with acute MI. PCSK9 was determined by enzyme-linked immunosorbent assay.Results. The mean PCSK9 levels were 479,7±15,4 ng/ml. No significant correlation was found between PCSK9 and total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides. In the group of smokers, a significant inverse correlation was found between the levels of PCSK9 and HDL-C (-0,45; p=0,039). In the group of patients with body mass index <25 kg/m2, a significant inverse correlation of PCSK9 levels with total cholesterol (-0,45, p=0,008), HDL-C (-0,42; p=0,029) and LDL-C (-0,47; p=0,003) was found.Conclusion. In patients with MI, a correlation of PCSK9 levels with lipid profile was found in smokers, as well as in patients with a low body mass index.https://russjcardiol.elpub.ru/jour/article/view/3724proprotein convertase subtilisin/kexin type 9myocardial infarction |
| spellingShingle | A. D. Gimadeeva A. S. Galyavich Z. M. Galeeva L. V. Baleeva Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction Российский кардиологический журнал proprotein convertase subtilisin/kexin type 9 myocardial infarction |
| title | Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction |
| title_full | Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction |
| title_fullStr | Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction |
| title_full_unstemmed | Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction |
| title_short | Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction |
| title_sort | levels of proprotein convertase subtilisin kexin type 9 in patients with acute myocardial infarction |
| topic | proprotein convertase subtilisin/kexin type 9 myocardial infarction |
| url | https://russjcardiol.elpub.ru/jour/article/view/3724 |
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