Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Current treatments for metastatic non-small cell lung cancer (NSCLC) have improved survival but remain non-curative, primarily aiming to control disease and to extend life. Structured exercise has demonstrated clinical and quality-of-life benefits in early-stage NSCLC. This systematic review assesse...
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MDPI AG
2025-05-01
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| Series: | Journal of Respiration |
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| Online Access: | https://www.mdpi.com/2673-527X/5/2/7 |
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| author | Carl Lawrence Arenos Franessa Ysabel Dianne Chan Huan-Jacinto Josephine Anne Lucero Frederic Ivan Ting Marvin Jonne Mendoza Madelaine Amante Danielle Benedict Sacdalan John Paulo Vergara |
| author_facet | Carl Lawrence Arenos Franessa Ysabel Dianne Chan Huan-Jacinto Josephine Anne Lucero Frederic Ivan Ting Marvin Jonne Mendoza Madelaine Amante Danielle Benedict Sacdalan John Paulo Vergara |
| author_sort | Carl Lawrence Arenos |
| collection | DOAJ |
| description | Current treatments for metastatic non-small cell lung cancer (NSCLC) have improved survival but remain non-curative, primarily aiming to control disease and to extend life. Structured exercise has demonstrated clinical and quality-of-life benefits in early-stage NSCLC. This systematic review assesses the impact of adjunctive exercise programs on health-related quality of life (HRQoL) in advanced NSCLC patients, with safety as a secondary outcome. Of 1168 studies screened, 13 met the inclusion criteria. All eligible studies were included in the systematic review, and three underwent meta-analysis. Using Synthesis Without Meta-analysis (SWiM), the findings were heterogeneous: four studies showed positive outcomes, two had mixed results, and seven showed negative outcomes. Meta-analysis of studies utilizing the EORTC-C30 tool demonstrated a positive mean difference of 1.57 (95% CI: 0 to 3.14), indicating a trend toward HRQoL improvement. Safety analyses largely revealed no major adverse events related to exercise interventions. Future studies must therefore be designed to account for confounders intrinsic to the underlying disease of study participants to better determine both the efficacy and the safety of structured, adjunctive exercise programs in this patient population. |
| format | Article |
| id | doaj-art-71badf8b28a449a09a62ee3cf741a5ab |
| institution | Matheson Library |
| issn | 2673-527X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Respiration |
| spelling | doaj-art-71badf8b28a449a09a62ee3cf741a5ab2025-06-25T14:02:50ZengMDPI AGJournal of Respiration2673-527X2025-05-0152710.3390/jor5020007Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsCarl Lawrence Arenos0Franessa Ysabel Dianne Chan Huan-Jacinto1Josephine Anne Lucero2Frederic Ivan Ting3Marvin Jonne Mendoza4Madelaine Amante5Danielle Benedict Sacdalan6John Paulo Vergara7Division of Medical Oncology, Department of Medicine, University of the Philippines—Philippine General Hospital, Manila 1000, PhilippinesDivision of Medical Oncology, Department of Medicine, University of the Philippines—Philippine General Hospital, Manila 1000, PhilippinesPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, CanadaDepartment of Clinical Sciences, University of St. La Salle College of Medicine, Bacolod City 6100, PhilippinesDepartment of Medicine, St. Luke’s Medical Center—Global City, Taguig City 1634, PhilippinesDepartment of Medicine, St. Luke’s Medical Center—Global City, Taguig City 1634, PhilippinesInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3H2, CanadaDivision of Medical Oncology, Department of Medicine, University of the Philippines—Philippine General Hospital, Manila 1000, PhilippinesCurrent treatments for metastatic non-small cell lung cancer (NSCLC) have improved survival but remain non-curative, primarily aiming to control disease and to extend life. Structured exercise has demonstrated clinical and quality-of-life benefits in early-stage NSCLC. This systematic review assesses the impact of adjunctive exercise programs on health-related quality of life (HRQoL) in advanced NSCLC patients, with safety as a secondary outcome. Of 1168 studies screened, 13 met the inclusion criteria. All eligible studies were included in the systematic review, and three underwent meta-analysis. Using Synthesis Without Meta-analysis (SWiM), the findings were heterogeneous: four studies showed positive outcomes, two had mixed results, and seven showed negative outcomes. Meta-analysis of studies utilizing the EORTC-C30 tool demonstrated a positive mean difference of 1.57 (95% CI: 0 to 3.14), indicating a trend toward HRQoL improvement. Safety analyses largely revealed no major adverse events related to exercise interventions. Future studies must therefore be designed to account for confounders intrinsic to the underlying disease of study participants to better determine both the efficacy and the safety of structured, adjunctive exercise programs in this patient population.https://www.mdpi.com/2673-527X/5/2/7lung cancerNSCLCexercisestructured exerciseadjunctive therapysystematic review |
| spellingShingle | Carl Lawrence Arenos Franessa Ysabel Dianne Chan Huan-Jacinto Josephine Anne Lucero Frederic Ivan Ting Marvin Jonne Mendoza Madelaine Amante Danielle Benedict Sacdalan John Paulo Vergara Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Respiration lung cancer NSCLC exercise structured exercise adjunctive therapy systematic review |
| title | Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | effects of structured exercise programs on self reported health related quality of life in patients with advanced non small cell lung cancer a systematic review and meta analysis of randomized controlled trials |
| topic | lung cancer NSCLC exercise structured exercise adjunctive therapy systematic review |
| url | https://www.mdpi.com/2673-527X/5/2/7 |
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