Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis.
<h4>Background</h4>A Mediterranean dietary pattern is widely recommended for the prevention of chronic disease. We sought to define the most likely effects of the Mediterranean diet on vascular disease and mortality.<h4>Methods</h4>We searched MEDLINE, EMBASE and the Cochrane...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0159252 |
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| author | Thaminda Liyanage Toshiharu Ninomiya Amanda Wang Amanda Wang Bruce Neal Min Jun Muh Geot Wong Meg Jardine Graham S Hillis Vlado Perkovic |
| author_facet | Thaminda Liyanage Toshiharu Ninomiya Amanda Wang Amanda Wang Bruce Neal Min Jun Muh Geot Wong Meg Jardine Graham S Hillis Vlado Perkovic |
| author_sort | Thaminda Liyanage |
| collection | DOAJ |
| description | <h4>Background</h4>A Mediterranean dietary pattern is widely recommended for the prevention of chronic disease. We sought to define the most likely effects of the Mediterranean diet on vascular disease and mortality.<h4>Methods</h4>We searched MEDLINE, EMBASE and the Cochrane Central Register without language restriction for randomized controlled trials comparing Mediterranean to control diets. Data on study design, patient characteristics, interventions, follow-up duration, outcomes and adverse events were sought. Individual study relative risks (RR) were pooled to create summary estimates.<h4>Results</h4>Six studies with a total of 10950 participants were included. Effects on major vascular events (n = 477), death (n = 693) and vascular deaths (n = 315) were reported for 3, 5 and 4 studies respectively. For one large study (n = 1000) there were serious concerns about the integrity of the data. When data for all studies were combined there was evidence of protection against major vascular events (RR 0.63, 95% confidence interval 0.53-0.75), coronary events (0.65, 0.50-0.85), stroke (0.65, 0.48-0.88) and heart failure (0.30, 0.17-0.56) but not for all-cause mortality (1.00, 0.86-1.15) or cardiovascular mortality (0.90, 0.72-1.11). After the study of concern was excluded the benefit for vascular events (0.69, 0.55-0.86) and stroke (0.66, 0.48-0.92) persisted but apparently positive findings for coronary events (0.73, 0.51-1.05) and heart failure (0.25, 0.05-1.17) disappeared.<h4>Conclusion</h4>The Mediterranean diet may protect against vascular disease. However, both the quantity and quality of the available evidence is limited and highly variable. Results must be interpreted with caution. |
| format | Article |
| id | doaj-art-71b644ebba5444b7a1c6543efb85fae1 |
| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-71b644ebba5444b7a1c6543efb85fae12025-06-30T05:32:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e015925210.1371/journal.pone.0159252Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis.Thaminda LiyanageToshiharu NinomiyaAmanda WangAmanda WangBruce NealMin JunMuh Geot WongMeg JardineGraham S HillisVlado Perkovic<h4>Background</h4>A Mediterranean dietary pattern is widely recommended for the prevention of chronic disease. We sought to define the most likely effects of the Mediterranean diet on vascular disease and mortality.<h4>Methods</h4>We searched MEDLINE, EMBASE and the Cochrane Central Register without language restriction for randomized controlled trials comparing Mediterranean to control diets. Data on study design, patient characteristics, interventions, follow-up duration, outcomes and adverse events were sought. Individual study relative risks (RR) were pooled to create summary estimates.<h4>Results</h4>Six studies with a total of 10950 participants were included. Effects on major vascular events (n = 477), death (n = 693) and vascular deaths (n = 315) were reported for 3, 5 and 4 studies respectively. For one large study (n = 1000) there were serious concerns about the integrity of the data. When data for all studies were combined there was evidence of protection against major vascular events (RR 0.63, 95% confidence interval 0.53-0.75), coronary events (0.65, 0.50-0.85), stroke (0.65, 0.48-0.88) and heart failure (0.30, 0.17-0.56) but not for all-cause mortality (1.00, 0.86-1.15) or cardiovascular mortality (0.90, 0.72-1.11). After the study of concern was excluded the benefit for vascular events (0.69, 0.55-0.86) and stroke (0.66, 0.48-0.92) persisted but apparently positive findings for coronary events (0.73, 0.51-1.05) and heart failure (0.25, 0.05-1.17) disappeared.<h4>Conclusion</h4>The Mediterranean diet may protect against vascular disease. However, both the quantity and quality of the available evidence is limited and highly variable. Results must be interpreted with caution.https://doi.org/10.1371/journal.pone.0159252 |
| spellingShingle | Thaminda Liyanage Toshiharu Ninomiya Amanda Wang Amanda Wang Bruce Neal Min Jun Muh Geot Wong Meg Jardine Graham S Hillis Vlado Perkovic Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. PLoS ONE |
| title | Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. |
| title_full | Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. |
| title_fullStr | Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. |
| title_full_unstemmed | Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. |
| title_short | Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. |
| title_sort | effects of the mediterranean diet on cardiovascular outcomes a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0159252 |
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