Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics
This study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinoma...
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| Language: | Russian |
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ABV-press
2022-09-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/977 |
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| author | O. G. Grigoruk T. A. Moskvina D. A. Tsoy A. S. Stepanova L. M. Bazulina E. S. Sigitova T. V. Ponomareva V. K. Ilinskiy Yu. A. Bryleva O. V. Samuylenkova S. Yu. Bakharev E. E. Pupkova A. V. Baron A. V. Fedoskina |
| author_facet | O. G. Grigoruk T. A. Moskvina D. A. Tsoy A. S. Stepanova L. M. Bazulina E. S. Sigitova T. V. Ponomareva V. K. Ilinskiy Yu. A. Bryleva O. V. Samuylenkova S. Yu. Bakharev E. E. Pupkova A. V. Baron A. V. Fedoskina |
| author_sort | O. G. Grigoruk |
| collection | DOAJ |
| description | This study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinomas in situ, were diagnosed using cytological methods over a year. Liquid-based cytology ensured better detection of glandular differentiation signs than conventional cytology. After molecular testing for human papillomavirus (HPV), we performed retrospective analysis of cytological characteristics of all endocervical adenocarcinomas (n = 15).We identified specific cellular characteristics of HPV-associated typical and mucinous adenocarcinomas. We also observed 1 case of non-HPV-related clear-cell and 1 case of non-HPV-related mesonephral adenocarcinoma.Our findings suggest that endocervical adenocarcinomas are a heterogeneous group of tumors. Endocervical adenocarcinomas accounted for 10.7 % of all primary cervical carcinomas (n = 214). Eighty percent of all endocervical adenocarcinomas were HPV-related, whereas the remaining 20 % were HPV-negative. We found no cytological differences between invasive endocervical adenocarcinomas and adenocarcinomas in situ.Mutations detected in some of the patients are an important diagnostic criterion that specifies whether the tumor is rare. |
| format | Article |
| id | doaj-art-71a06a552ac14d5e88f1fbdabd8864db |
| institution | Matheson Library |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2022-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-71a06a552ac14d5e88f1fbdabd8864db2025-08-04T14:33:42ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272022-09-0118210911810.17650/1994-4098-2022-18-2-109-118743Endocervical adenocarcinomas. Cytological, histological, and molecular diagnosticsO. G. Grigoruk0T. A. Moskvina1D. A. Tsoy2A. S. Stepanova3L. M. Bazulina4E. S. Sigitova5T. V. Ponomareva6V. K. Ilinskiy7Yu. A. Bryleva8O. V. Samuylenkova9S. Yu. Bakharev10E. E. Pupkova11A. V. Baron12A. V. Fedoskina13Altai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaAltai Regional Oncology Dispensary; Altai State Medical University, Ministry of Health of RussiaThis study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinomas in situ, were diagnosed using cytological methods over a year. Liquid-based cytology ensured better detection of glandular differentiation signs than conventional cytology. After molecular testing for human papillomavirus (HPV), we performed retrospective analysis of cytological characteristics of all endocervical adenocarcinomas (n = 15).We identified specific cellular characteristics of HPV-associated typical and mucinous adenocarcinomas. We also observed 1 case of non-HPV-related clear-cell and 1 case of non-HPV-related mesonephral adenocarcinoma.Our findings suggest that endocervical adenocarcinomas are a heterogeneous group of tumors. Endocervical adenocarcinomas accounted for 10.7 % of all primary cervical carcinomas (n = 214). Eighty percent of all endocervical adenocarcinomas were HPV-related, whereas the remaining 20 % were HPV-negative. We found no cytological differences between invasive endocervical adenocarcinomas and adenocarcinomas in situ.Mutations detected in some of the patients are an important diagnostic criterion that specifies whether the tumor is rare.https://ojrs.abvpress.ru/ojrs/article/view/977endocervical adenocarcinomacytological and histological diagnosticsliquid-based cytologyimmunohistochemical hpv typing of adenocarcinomasmutations in the kras gene in mesonephric tumors |
| spellingShingle | O. G. Grigoruk T. A. Moskvina D. A. Tsoy A. S. Stepanova L. M. Bazulina E. S. Sigitova T. V. Ponomareva V. K. Ilinskiy Yu. A. Bryleva O. V. Samuylenkova S. Yu. Bakharev E. E. Pupkova A. V. Baron A. V. Fedoskina Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics Опухоли женской репродуктивной системы endocervical adenocarcinoma cytological and histological diagnostics liquid-based cytology immunohistochemical hpv typing of adenocarcinomas mutations in the kras gene in mesonephric tumors |
| title | Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics |
| title_full | Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics |
| title_fullStr | Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics |
| title_full_unstemmed | Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics |
| title_short | Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics |
| title_sort | endocervical adenocarcinomas cytological histological and molecular diagnostics |
| topic | endocervical adenocarcinoma cytological and histological diagnostics liquid-based cytology immunohistochemical hpv typing of adenocarcinomas mutations in the kras gene in mesonephric tumors |
| url | https://ojrs.abvpress.ru/ojrs/article/view/977 |
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