Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes
IntroductionThere is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of increased arterial stiffness (AS) and reduced cerebral blood flo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1466294/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839642255614279680 |
|---|---|
| author | Michelle Horan Michelle Horan Daniel Carey Daniel Carey Silvin Knight Silvin Knight A. Fagan James F. M. Meaney James F. M. Meaney Rose Anne Kenny Rose Anne Kenny Rose Anne Kenny Céline De Looze Céline De Looze |
| author_facet | Michelle Horan Michelle Horan Daniel Carey Daniel Carey Silvin Knight Silvin Knight A. Fagan James F. M. Meaney James F. M. Meaney Rose Anne Kenny Rose Anne Kenny Rose Anne Kenny Céline De Looze Céline De Looze |
| author_sort | Michelle Horan |
| collection | DOAJ |
| description | IntroductionThere is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of increased arterial stiffness (AS) and reduced cerebral blood flow (CBF) on hippocampal volume (HV) in a large MRI sample of community-dwelling older adults from the Irish Longitudinal Study on Ageing (TILDA).MethodsLongitudinal data from study participants for Wave 1 (2009–2011) and Wave 3 (2014-2015) were included. This included health and social information as well as a nurse-administered health assessment. Patients who had complete AS, CBF and MR-hippocampal measurements were included. Pseudo-continuous arterial spine labelling was performed to quantify whole CBF. Volumetric analysis was performed using FreeSurfer 6.0 recon-all processing pipeline.Results395 patients met inclusion criteria. This four-year follow up longitudinal study demonstrated that (i) prolonged elevated AS (at wave 1 and wave 3), (ii) the interaction between higher AS at wave 1 and lower CBF at wave 3 and (iii) the interaction between prolonged elevated AS (at wave 1 and wave 3) and reduced CBF at wave 3 were associated with smaller HV.ConclusionIncreased arterial stiffness and reduced CBF were not independently associated with smaller HV. However, in combination, persistently elevated AS and reduced CBF is associated with smaller HV. These effects were equally exerted across all hippocampal subfields tested. Our findings suggest a lag effect in the arterial stiffness and hippocampal volume relationship. We propose that the subsequent reduction in cerebral blood flow observed with elevated arterial stiffness may be the missing link in the pathway associating arterial stiffness with hippocampal atrophy. |
| format | Article |
| id | doaj-art-70a9ee13d4ac4a43b4fb39b10e863c63 |
| institution | Matheson Library |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-70a9ee13d4ac4a43b4fb39b10e863c632025-07-02T12:26:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-06-011710.3389/fnagi.2025.14662941466294Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumesMichelle Horan0Michelle Horan1Daniel Carey2Daniel Carey3Silvin Knight4Silvin Knight5A. Fagan6James F. M. Meaney7James F. M. Meaney8Rose Anne Kenny9Rose Anne Kenny10Rose Anne Kenny11Céline De Looze12Céline De Looze13The Thomas Mitchell Centre for Advanced Medical Imaging (CAMI), St. James’ Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, IrelandThe Thomas Mitchell Centre for Advanced Medical Imaging (CAMI), St. James’ Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, IrelandMercer’s Institute for Successful Ageing, St. James’ Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, IrelandIntroductionThere is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of increased arterial stiffness (AS) and reduced cerebral blood flow (CBF) on hippocampal volume (HV) in a large MRI sample of community-dwelling older adults from the Irish Longitudinal Study on Ageing (TILDA).MethodsLongitudinal data from study participants for Wave 1 (2009–2011) and Wave 3 (2014-2015) were included. This included health and social information as well as a nurse-administered health assessment. Patients who had complete AS, CBF and MR-hippocampal measurements were included. Pseudo-continuous arterial spine labelling was performed to quantify whole CBF. Volumetric analysis was performed using FreeSurfer 6.0 recon-all processing pipeline.Results395 patients met inclusion criteria. This four-year follow up longitudinal study demonstrated that (i) prolonged elevated AS (at wave 1 and wave 3), (ii) the interaction between higher AS at wave 1 and lower CBF at wave 3 and (iii) the interaction between prolonged elevated AS (at wave 1 and wave 3) and reduced CBF at wave 3 were associated with smaller HV.ConclusionIncreased arterial stiffness and reduced CBF were not independently associated with smaller HV. However, in combination, persistently elevated AS and reduced CBF is associated with smaller HV. These effects were equally exerted across all hippocampal subfields tested. Our findings suggest a lag effect in the arterial stiffness and hippocampal volume relationship. We propose that the subsequent reduction in cerebral blood flow observed with elevated arterial stiffness may be the missing link in the pathway associating arterial stiffness with hippocampal atrophy.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1466294/fullcognitive impairmentarterial stiffeningcerebral blood flowhippocampushippocampal subfield atrophy |
| spellingShingle | Michelle Horan Michelle Horan Daniel Carey Daniel Carey Silvin Knight Silvin Knight A. Fagan James F. M. Meaney James F. M. Meaney Rose Anne Kenny Rose Anne Kenny Rose Anne Kenny Céline De Looze Céline De Looze Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes Frontiers in Aging Neuroscience cognitive impairment arterial stiffening cerebral blood flow hippocampus hippocampal subfield atrophy |
| title | Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| title_full | Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| title_fullStr | Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| title_full_unstemmed | Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| title_short | Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| title_sort | examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes |
| topic | cognitive impairment arterial stiffening cerebral blood flow hippocampus hippocampal subfield atrophy |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1466294/full |
| work_keys_str_mv | AT michellehoran examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT michellehoran examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT danielcarey examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT danielcarey examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT silvinknight examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT silvinknight examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT afagan examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT jamesfmmeaney examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT jamesfmmeaney examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT roseannekenny examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT roseannekenny examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT roseannekenny examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT celinedelooze examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes AT celinedelooze examiningtheindependentandmoderatingeffectsofarterialstiffnessandcerebralbloodflowontotalhippocampalandhippocampalsubfieldvolumes |