Confirmation of validity of the developed translational model of chronic heart failure in rats
The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals there is a significant increase in the endsystoli...
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| Format: | Article |
| Language: | Russian |
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2020-12-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/243 |
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| author | I. B. Tsorin V. V. Barchukov E. O. Ionova V. N. Stolayruk M. B. Vititnova S. A. Kryzhanovskii |
| author_facet | I. B. Tsorin V. V. Barchukov E. O. Ionova V. N. Stolayruk M. B. Vititnova S. A. Kryzhanovskii |
| author_sort | I. B. Tsorin |
| collection | DOAJ |
| description | The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals there is a significant increase in the endsystolic and end-diastolic sizes of the left ventricle (respectively, from 2.49 ± 0.09 to 3.91 ± 0.17 mm, p = 0.0002, and from 3.56 ± 0.12 to 5.20 ± 0.19 mm, p = 0.0002) and the decrease of its inotropic function that indicates a simulated pathology. 5 days after the echocardiographic study, the animals' exercise tolerance was assessed in the treadmill-run to failure test. It is proved in rats that 90 days after the coronary artery litigation the tolerance of physical activity decreases sharply – the value of the distance covered by them is 109.21 ± 11.61 m, which is 2.5 times less than the distance covered by sham operated animals (p = 0.003) and 5.3 times less than the distance covered by intact rats (p = 0.0001), – which is pathognomonic for chronic heart failure and complements the data of previously conducted morpho-histological, biochemical and molecular studies, indicating that the present model reproduces the main clinical and diagnostic signs of the simulated pathology. |
| format | Article |
| id | doaj-art-706075d132da46008d4b64af4b7df1fe |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | LLC “Publisher OKI” |
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| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-706075d132da46008d4b64af4b7df1fe2025-08-03T13:00:47ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302020-12-0102111610.37489/2587-7836-2020-2-11-16240Confirmation of validity of the developed translational model of chronic heart failure in ratsI. B. Tsorin0V. V. Barchukov1E. O. Ionova2V. N. Stolayruk3M. B. Vititnova4S. A. Kryzhanovskii5FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals there is a significant increase in the endsystolic and end-diastolic sizes of the left ventricle (respectively, from 2.49 ± 0.09 to 3.91 ± 0.17 mm, p = 0.0002, and from 3.56 ± 0.12 to 5.20 ± 0.19 mm, p = 0.0002) and the decrease of its inotropic function that indicates a simulated pathology. 5 days after the echocardiographic study, the animals' exercise tolerance was assessed in the treadmill-run to failure test. It is proved in rats that 90 days after the coronary artery litigation the tolerance of physical activity decreases sharply – the value of the distance covered by them is 109.21 ± 11.61 m, which is 2.5 times less than the distance covered by sham operated animals (p = 0.003) and 5.3 times less than the distance covered by intact rats (p = 0.0001), – which is pathognomonic for chronic heart failure and complements the data of previously conducted morpho-histological, biochemical and molecular studies, indicating that the present model reproduces the main clinical and diagnostic signs of the simulated pathology.https://www.pharmacokinetica.ru/jour/article/view/243translational modelchronic postinfarction heart failureanterior transmural myocardial infarctionechocardiographyexercise tolerancevalidity |
| spellingShingle | I. B. Tsorin V. V. Barchukov E. O. Ionova V. N. Stolayruk M. B. Vititnova S. A. Kryzhanovskii Confirmation of validity of the developed translational model of chronic heart failure in rats Фармакокинетика и Фармакодинамика translational model chronic postinfarction heart failure anterior transmural myocardial infarction echocardiography exercise tolerance validity |
| title | Confirmation of validity of the developed translational model of chronic heart failure in rats |
| title_full | Confirmation of validity of the developed translational model of chronic heart failure in rats |
| title_fullStr | Confirmation of validity of the developed translational model of chronic heart failure in rats |
| title_full_unstemmed | Confirmation of validity of the developed translational model of chronic heart failure in rats |
| title_short | Confirmation of validity of the developed translational model of chronic heart failure in rats |
| title_sort | confirmation of validity of the developed translational model of chronic heart failure in rats |
| topic | translational model chronic postinfarction heart failure anterior transmural myocardial infarction echocardiography exercise tolerance validity |
| url | https://www.pharmacokinetica.ru/jour/article/view/243 |
| work_keys_str_mv | AT ibtsorin confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats AT vvbarchukov confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats AT eoionova confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats AT vnstolayruk confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats AT mbvititnova confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats AT sakryzhanovskii confirmationofvalidityofthedevelopedtranslationalmodelofchronicheartfailureinrats |