Distribution Study of 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide and Its Metabolites in Rats

Distribution Study of 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide and Its Metabolites in Rats

INTRODUCTION. This article continues a series of publications on the pharmacokinetics of 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide (TFISA), a novel compound for the treatment of open-angle glaucoma. The distribution of TFISA and its metabolites in rat organs and tissues has not be...

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Bibliographic Details
Main Authors: I. I. Yaichkov, A. L. Khokhlov, M. K. Korsakov, N. N. Volkhin, S. S. Petukhov, O. E. Lazariants, A. V. Korovina
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2025-07-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
carbonic anhydrase ii inhibitor, n-hydroxy sulfonamide
eye drops
rats
hplc–ms/ms
validation
distribution
pharmacokinetics
glaucoma
preclinical studies
Online Access:https://www.vedomostincesmp.ru/jour/article/view/743
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