Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>
Relevance. The increase in the frequency of infections caused by Pseudomonas aeruginosa and Acinetobacter baumannii, which have a high level of resistance to many groups of antibiotics, requires a comprehensive study, including modern research methods.Aims. The study of regional features of the dyna...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2020-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/862 |
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| author | Yu. E. Skurikhina V. B. Turkutyukov |
| author_facet | Yu. E. Skurikhina V. B. Turkutyukov |
| author_sort | Yu. E. Skurikhina |
| collection | DOAJ |
| description | Relevance. The increase in the frequency of infections caused by Pseudomonas aeruginosa and Acinetobacter baumannii, which have a high level of resistance to many groups of antibiotics, requires a comprehensive study, including modern research methods.Aims. The study of regional features of the dynamics of the formation and circulation of antibiotic-resistant strains A. baumannii and P. aeruginosa.Materials and methods. During 2009-2018 we analyzed the data of microbiological laboratories of multidisciplinary hospitals and carried out a molecular genetic study of the determinants of antibiotic resistance by PCR of A. baumannii and P. aeruginosa strains isolated from clinical material in order to determine the level of variability of resistance.Results. The study revealed a tendency to increase in the proportion of strains A. baumannii and P. aeruginosa in the etiological structure of healh-care associated infections and purulent-septic infections; high incidence of strains resistant to cephalosporins, carbapenems, beta-lactams and multi-resistant strains. The appearance and distribution of the determinants of antibiotic resistance NDM-1 and MCR-1 in these bacteria were also detected.Conclusions. Over the past decade, a steady increase in the proportion of A. baumannii and P. Aeruginosa resistant to many antibiotics in patients in intensive care unit and surgery departments in hospitals of Vladivostok (Primorsky reg., Russia), and the emergence of new antimicrobial resistance mechanisms in these microorganisms. |
| format | Article |
| id | doaj-art-6f9c6bc7d0854dddaa6e7a2b76d23c48 |
| institution | Matheson Library |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2020-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-6f9c6bc7d0854dddaa6e7a2b76d23c482025-08-04T13:02:03ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942020-01-01186343810.31631/2073-3046-2019-18-6-34-38590Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>Yu. E. Skurikhina0V. B. Turkutyukov1Pacific State Medical UniversityPacific State Medical UniversityRelevance. The increase in the frequency of infections caused by Pseudomonas aeruginosa and Acinetobacter baumannii, which have a high level of resistance to many groups of antibiotics, requires a comprehensive study, including modern research methods.Aims. The study of regional features of the dynamics of the formation and circulation of antibiotic-resistant strains A. baumannii and P. aeruginosa.Materials and methods. During 2009-2018 we analyzed the data of microbiological laboratories of multidisciplinary hospitals and carried out a molecular genetic study of the determinants of antibiotic resistance by PCR of A. baumannii and P. aeruginosa strains isolated from clinical material in order to determine the level of variability of resistance.Results. The study revealed a tendency to increase in the proportion of strains A. baumannii and P. aeruginosa in the etiological structure of healh-care associated infections and purulent-septic infections; high incidence of strains resistant to cephalosporins, carbapenems, beta-lactams and multi-resistant strains. The appearance and distribution of the determinants of antibiotic resistance NDM-1 and MCR-1 in these bacteria were also detected.Conclusions. Over the past decade, a steady increase in the proportion of A. baumannii and P. Aeruginosa resistant to many antibiotics in patients in intensive care unit and surgery departments in hospitals of Vladivostok (Primorsky reg., Russia), and the emergence of new antimicrobial resistance mechanisms in these microorganisms.https://www.epidemvac.ru/jour/article/view/862pseudomonas aeruginosaacinetobacter baumanniihealth-care associated infectionspurulent-septic infectionsantibiotic resistancemetallo-beta-lactamase |
| spellingShingle | Yu. E. Skurikhina V. B. Turkutyukov Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> Эпидемиология и вакцинопрофилактика pseudomonas aeruginosa acinetobacter baumannii health-care associated infections purulent-septic infections antibiotic resistance metallo-beta-lactamase |
| title | Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> |
| title_full | Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> |
| title_fullStr | Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> |
| title_full_unstemmed | Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> |
| title_short | Microbiological and Molecular Genetic Aspects of Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> |
| title_sort | microbiological and molecular genetic aspects of antibiotic resistance of i pseudomonas aeruginosa i and i acinetobacter baumannii i |
| topic | pseudomonas aeruginosa acinetobacter baumannii health-care associated infections purulent-septic infections antibiotic resistance metallo-beta-lactamase |
| url | https://www.epidemvac.ru/jour/article/view/862 |
| work_keys_str_mv | AT yueskurikhina microbiologicalandmoleculargeneticaspectsofantibioticresistanceofipseudomonasaeruginosaiandiacinetobacterbaumanniii AT vbturkutyukov microbiologicalandmoleculargeneticaspectsofantibioticresistanceofipseudomonasaeruginosaiandiacinetobacterbaumanniii |