Immunosuppressive therapy in non-infections uveitis and retinovasculitis
Purpose: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.Methods: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 mg once a week (n=79) cyclosporine A 3.5-5.0 mg...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2014-07-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/140 |
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| _version_ | 1839571278313291776 |
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| author | E. A. Drozdova |
| author_facet | E. A. Drozdova |
| author_sort | E. A. Drozdova |
| collection | DOAJ |
| description | Purpose: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.Methods: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 mg once a week (n=79) cyclosporine A 3.5-5.0 mg/kg/d (n=21) with prednisone or other antimetabolites and local corticosteroid therapy for severe forms of inflammatory eye diseases.Results: the efficacy of methotrexate as monotherapy was 51.8% of patients with chronic uveitis. Control of acute inflammation was achived in 71.1% patients, who received methotrexate in combination with prednisolone. Cyclosporine A was more effective in controlling inflammatory of the eye: remission of uveitis was achived in 85.7% in combination with glucocorticoids. No significant side effects have been noted.Conclusion: Methotrexate and cyclosporine A with low dose of prednisolone are well tolerated immunosuppressive agents andrather effective in the treatment of non-infectious uveitis and retinovasculitis that fails to respond to conventional steroid treatment. |
| format | Article |
| id | doaj-art-6ecfd9284b7743de955fb8a70cc94eec |
| institution | Matheson Library |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-6ecfd9284b7743de955fb8a70cc94eec2025-08-04T14:32:17ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452014-07-0192586110.18008/1816-5095-2012-2-58-61140Immunosuppressive therapy in non-infections uveitis and retinovasculitisE. A. Drozdova0Государственное бюджетное образовательное учреждение высшего профессионального образования «Челябинская государственная медицинская академия» Минздравсоцразвития России, Челябинск, Россия, 454092 Челябинск, ул. Воровского, 64Purpose: to evaluate the efficacy and safety of the immunosuppressive therapy for severe forms of non-infections uveitis and retinovasculitis.Methods: 107 patients (62 males and 45 females aged 9 to 54 years) who received low dose methotrexate — 7.5-20 mg once a week (n=79) cyclosporine A 3.5-5.0 mg/kg/d (n=21) with prednisone or other antimetabolites and local corticosteroid therapy for severe forms of inflammatory eye diseases.Results: the efficacy of methotrexate as monotherapy was 51.8% of patients with chronic uveitis. Control of acute inflammation was achived in 71.1% patients, who received methotrexate in combination with prednisolone. Cyclosporine A was more effective in controlling inflammatory of the eye: remission of uveitis was achived in 85.7% in combination with glucocorticoids. No significant side effects have been noted.Conclusion: Methotrexate and cyclosporine A with low dose of prednisolone are well tolerated immunosuppressive agents andrather effective in the treatment of non-infectious uveitis and retinovasculitis that fails to respond to conventional steroid treatment.https://www.ophthalmojournal.com/opht/article/view/140uveitisretinovasculitisimmunosuppressive agents |
| spellingShingle | E. A. Drozdova Immunosuppressive therapy in non-infections uveitis and retinovasculitis Oftalʹmologiâ uveitis retinovasculitis immunosuppressive agents |
| title | Immunosuppressive therapy in non-infections uveitis and retinovasculitis |
| title_full | Immunosuppressive therapy in non-infections uveitis and retinovasculitis |
| title_fullStr | Immunosuppressive therapy in non-infections uveitis and retinovasculitis |
| title_full_unstemmed | Immunosuppressive therapy in non-infections uveitis and retinovasculitis |
| title_short | Immunosuppressive therapy in non-infections uveitis and retinovasculitis |
| title_sort | immunosuppressive therapy in non infections uveitis and retinovasculitis |
| topic | uveitis retinovasculitis immunosuppressive agents |
| url | https://www.ophthalmojournal.com/opht/article/view/140 |
| work_keys_str_mv | AT eadrozdova immunosuppressivetherapyinnoninfectionsuveitisandretinovasculitis |