Optimization of Vaccine Virus Accumulation in the Development of Smallpox Drugs Based on Cell Cultures

Optimization of Vaccine Virus Accumulation in the Development of Smallpox Drugs Based on Cell Cultures

Objective. Optimization of vaccine virus cultivation in the suspended cell culture BHK-21 for infectious activity increment of virus-containing suspension as the base material for smallpox vaccine preparations. Materials and methods. We used suspended culture line of the cells BHK-21 of 72-hour age...

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Bibliographic Details
Main Authors: A. V. Ovchinnikov, G. V. Borisevich, A. I. Terent’ev, Yu. I. Pashchenko, V. T. Krotkov, V. N. Marchenko, S. V. Borisevich, S. L. Kuznetsov
Format: Article
Language:Russian
Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2019-04-01
Series:Проблемы особо опасных инфекций
Subjects:
culture of bhk-21 cells
virus of the vaccine
bioreactor
suspension cultivation of cells
Online Access:https://journal.microbe.ru/jour/article/view/1132
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