Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients
BackgroundProkineticin 2 is associated with the macrophages-mediated biological process, neuronal death, oxidative stress, and inflammatory processes, while its clinical value in patients with acute ischemic stroke (AIS) has not been explored. This study aimed to evaluate the level of prokineticin 2...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1559688/full |
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| author | Lixiao Sun Yuxin Fu Jiecheng Yang Xiaoli Wang Dongsheng Cui Qiang Feng Xuguang Song Zhe Li Zhuangwei Wang Wenchao Wang Yiping Wu Jingmei Wang |
| author_facet | Lixiao Sun Yuxin Fu Jiecheng Yang Xiaoli Wang Dongsheng Cui Qiang Feng Xuguang Song Zhe Li Zhuangwei Wang Wenchao Wang Yiping Wu Jingmei Wang |
| author_sort | Lixiao Sun |
| collection | DOAJ |
| description | BackgroundProkineticin 2 is associated with the macrophages-mediated biological process, neuronal death, oxidative stress, and inflammatory processes, while its clinical value in patients with acute ischemic stroke (AIS) has not been explored. This study aimed to evaluate the level of prokineticin 2 and its association with inflammatory indexes and functional recovery in AIS patients.MethodsSerum samples in 210 AIS patients at admission and in 30 healthy subjects at enrollment were collected. Then, prokineticin 2 levels were determined by enzyme-linked immunosorbent assay.ResultsProkineticin 2 level was higher in AIS patients than healthy subjects (p < 0.001). Prokineticin 2 showed an acceptable ability to distinguish the AIS patients from healthy subjects (area under the curve: 0.812) with the best cut-off value at 4 ng/mL. No matter dividing the prokineticin 2 by continuous variable or quartiles, its value was positively correlated with the high sensitivity C reactive protein (HsCRP), tumor necrosis factor-alpha (TNF-α), and interleukin 17A (IL-17A) (all p < 0.001). Prokineticin 2 showed a higher trend in AIS patients with Modified Rankin Scale (mRS) score>2 compared with those with mRS score ≤2, but without statistical significance (p = 0.095). Besides, there was no association between prokineticin 2 by quartiles and the percentage of mRS > 2 (p > 0.05).ConclusionProkineticin 2 aberrantly highly expresses, and it indicates the inflammatory status, but with limited ability to predict the neural functional recovery in AIS patients. |
| format | Article |
| id | doaj-art-6daf2ec2ceaf40b4b7819d290cbf1edb |
| institution | Matheson Library |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-6daf2ec2ceaf40b4b7819d290cbf1edb2025-07-10T04:11:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.15596881559688Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patientsLixiao Sun0Yuxin Fu1Jiecheng Yang2Xiaoli Wang3Dongsheng Cui4Qiang Feng5Xuguang Song6Zhe Li7Zhuangwei Wang8Wenchao Wang9Yiping Wu10Jingmei Wang11Department of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaChild Care, Merice Cody Public School, Toronto, ON, CanadaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Cardiology, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaDepartment of Neurology, Handan Central Hospital, Handan, ChinaDepartment of Neurology, Handan Central Hospital, Handan, ChinaDepartment of Critical Care Medicine, Handan Central Hospital, Handan, ChinaBackgroundProkineticin 2 is associated with the macrophages-mediated biological process, neuronal death, oxidative stress, and inflammatory processes, while its clinical value in patients with acute ischemic stroke (AIS) has not been explored. This study aimed to evaluate the level of prokineticin 2 and its association with inflammatory indexes and functional recovery in AIS patients.MethodsSerum samples in 210 AIS patients at admission and in 30 healthy subjects at enrollment were collected. Then, prokineticin 2 levels were determined by enzyme-linked immunosorbent assay.ResultsProkineticin 2 level was higher in AIS patients than healthy subjects (p < 0.001). Prokineticin 2 showed an acceptable ability to distinguish the AIS patients from healthy subjects (area under the curve: 0.812) with the best cut-off value at 4 ng/mL. No matter dividing the prokineticin 2 by continuous variable or quartiles, its value was positively correlated with the high sensitivity C reactive protein (HsCRP), tumor necrosis factor-alpha (TNF-α), and interleukin 17A (IL-17A) (all p < 0.001). Prokineticin 2 showed a higher trend in AIS patients with Modified Rankin Scale (mRS) score>2 compared with those with mRS score ≤2, but without statistical significance (p = 0.095). Besides, there was no association between prokineticin 2 by quartiles and the percentage of mRS > 2 (p > 0.05).ConclusionProkineticin 2 aberrantly highly expresses, and it indicates the inflammatory status, but with limited ability to predict the neural functional recovery in AIS patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1559688/fullacute ischemic strokeprokineticin 2inflammatory statusfunctional recoveryMRS |
| spellingShingle | Lixiao Sun Yuxin Fu Jiecheng Yang Xiaoli Wang Dongsheng Cui Qiang Feng Xuguang Song Zhe Li Zhuangwei Wang Wenchao Wang Yiping Wu Jingmei Wang Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients Frontiers in Neurology acute ischemic stroke prokineticin 2 inflammatory status functional recovery MRS |
| title | Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| title_full | Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| title_fullStr | Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| title_full_unstemmed | Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| title_short | Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| title_sort | aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients |
| topic | acute ischemic stroke prokineticin 2 inflammatory status functional recovery MRS |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1559688/full |
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