P2X7 receptor as a key player in pathological pain: insights into Neuropathic, inflammatory, and cancer pain

P2X7 receptor as a key player in pathological pain: insights into Neuropathic, inflammatory, and cancer pain

Purinergic P2X7 receptor (P2X7R) is a widely distributed, non-selective ATP-gated ion channel that plays a crucial role in the regulation of neuropathic pain, inflammatory pain, and cancer pain. Understanding the function and mechanisms of P2X7R in these various pain conditions, as well as utilizing...

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Bibliographic Details
Main Authors: Pan Jiang, Cai Wang, Fajing Jia, Hua Wu, Haihu Hao, Shaoze Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
P2X7 receptor
pathological pain
neuropathic pain
inflammatory pain
cancer pain
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1585545/full
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