Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury

Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury

Summary: Excessive inflammation contributes to tissue injury in conditions including acute respiratory distress syndrome and ischemia-reperfusion. Moderation of inflammation is a potential therapeutic approach. A phenotypic screen of chemical libraries in influenza A-infected zebrafish identified ae...

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Bibliographic Details
Main Authors: Elyse Latreille, Avinash Naraiah Mukkala, Rajiv Sanwal, Junghwa Yun, Kuiru Wei, Raluca Petrut, Nikki Zamani Farahani, Tristan Philip, Leo Xu, Tom Bateman, Chuxi Pan, David E. Williams, Trevor Moraes, Xiao-Yan Wen, Ori Rotstein, Raymond J. Andersen, Warren L. Lee
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Therapeutics
Marine organism
Phenotyping
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013264
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