Serum TSH level in hospitalized patients with moderate-to-severe COVID-19
Objective: to measure the serum TSH level in hospitalized patients with moderate-to-severe COVID-19.Material and methods: this was a retrospective study at Almazov National Medical Research Centre enrolled 133 hospitalized COVID-19 patients without known thyroid disorders. Clinical data, biochemical...
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2022-03-01
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| Series: | Медицинский вестник Юга России |
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| Online Access: | https://www.medicalherald.ru/jour/article/view/1491 |
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| author | A. A. Mikhailova D. I. Lagutina K. A. Golovatuk T. L. Karonova A. T. Andreeva E. Yu Vasilieva E. N. Grineva |
| author_facet | A. A. Mikhailova D. I. Lagutina K. A. Golovatuk T. L. Karonova A. T. Andreeva E. Yu Vasilieva E. N. Grineva |
| author_sort | A. A. Mikhailova |
| collection | DOAJ |
| description | Objective: to measure the serum TSH level in hospitalized patients with moderate-to-severe COVID-19.Material and methods: this was a retrospective study at Almazov National Medical Research Centre enrolled 133 hospitalized COVID-19 patients without known thyroid disorders. Clinical data, biochemical parameters (TSH, 25(OH)D, C-reactive protein, Lactate dehydrogenase and Ferritin), fi ndings of chest computed tomography (CT) imaging as well as obtained corticosteroids therapy were analyzed.Results: the median TSH level at the 1st-2nd day of hospitalization and at the 9-10th day was 1,15 mIU/L [0, 76; 1, 8] and 1,04 mIU/L [0,7; 1,78] respectively. Th e initial level of TSH <0,4 mIU/L was found in four patients, while by the 9-10th day of hospitalization their number doubled and reached 9 (11,7%). Furthermore, by the 9-10th day of hospitalization the TSH level more than 4,5 mIU/L was detected in four patients (4,2%). Th us, 13 out of 77 patients had the serum TSH level outside the reference range by the 9-10th day of hospitalization.Conclusions: in case of alteration in the serum TSH level it is necessary to take into account the personal history of thyroid disorders. Th e level of thyroid hormones and autoimmune markers as well as thyroid ultrasound results may be useful in clinical interpretation of thyroidal insults during and aft er COVID-19. Th e hypothalamic-pituitary-thyroid axis may also be aff ected by drugs used to treat COVID-19. |
| format | Article |
| id | doaj-art-6d0ec3583e6541dea55d24f67ae4e4a3 |
| institution | Matheson Library |
| issn | 2219-8075 2618-7876 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj-art-6d0ec3583e6541dea55d24f67ae4e4a32025-07-03T16:13:40ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762022-03-01131727910.21886/2219-8075-2022-13-1-72-79858Serum TSH level in hospitalized patients with moderate-to-severe COVID-19A. A. Mikhailova0D. I. Lagutina1K. A. Golovatuk2T. L. Karonova3A. T. Andreeva4E. Yu Vasilieva5E. N. Grineva6V.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreV.A. Almazov National Medical Research CentreObjective: to measure the serum TSH level in hospitalized patients with moderate-to-severe COVID-19.Material and methods: this was a retrospective study at Almazov National Medical Research Centre enrolled 133 hospitalized COVID-19 patients without known thyroid disorders. Clinical data, biochemical parameters (TSH, 25(OH)D, C-reactive protein, Lactate dehydrogenase and Ferritin), fi ndings of chest computed tomography (CT) imaging as well as obtained corticosteroids therapy were analyzed.Results: the median TSH level at the 1st-2nd day of hospitalization and at the 9-10th day was 1,15 mIU/L [0, 76; 1, 8] and 1,04 mIU/L [0,7; 1,78] respectively. Th e initial level of TSH <0,4 mIU/L was found in four patients, while by the 9-10th day of hospitalization their number doubled and reached 9 (11,7%). Furthermore, by the 9-10th day of hospitalization the TSH level more than 4,5 mIU/L was detected in four patients (4,2%). Th us, 13 out of 77 patients had the serum TSH level outside the reference range by the 9-10th day of hospitalization.Conclusions: in case of alteration in the serum TSH level it is necessary to take into account the personal history of thyroid disorders. Th e level of thyroid hormones and autoimmune markers as well as thyroid ultrasound results may be useful in clinical interpretation of thyroidal insults during and aft er COVID-19. Th e hypothalamic-pituitary-thyroid axis may also be aff ected by drugs used to treat COVID-19.https://www.medicalherald.ru/jour/article/view/1491covid-19thyroid glandtshsars-cov-2hypothyroidismhyperthyroidism |
| spellingShingle | A. A. Mikhailova D. I. Lagutina K. A. Golovatuk T. L. Karonova A. T. Andreeva E. Yu Vasilieva E. N. Grineva Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 Медицинский вестник Юга России covid-19 thyroid gland tsh sars-cov-2 hypothyroidism hyperthyroidism |
| title | Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 |
| title_full | Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 |
| title_fullStr | Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 |
| title_full_unstemmed | Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 |
| title_short | Serum TSH level in hospitalized patients with moderate-to-severe COVID-19 |
| title_sort | serum tsh level in hospitalized patients with moderate to severe covid 19 |
| topic | covid-19 thyroid gland tsh sars-cov-2 hypothyroidism hyperthyroidism |
| url | https://www.medicalherald.ru/jour/article/view/1491 |
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